FlyBase Allele Report: Dmel\by[UAS.cLa]

General Information

Symbol

Dmel\by^UAS.cLa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Lee

FlyBase ID

FBal0152078

Feature type

allele

Associated gene

Dmel\by

Associated Insertion(s)

Carried in Construct

P{UAS-by.L}

Key Links

Transgenic product class

wild_type

(Lee et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Lee et al., 2003)

Mutagen

in vitro construct

(Lee et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-by.L}

Cytology

Description

UASt regulatory sequences drive expression of full length by.

(Lee et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^Bx-MS1096

(Lee et al., 2003)

visible, with Scer\GAL4^Bx-MS1096

(Lee et al., 2003)

Phenotype Manifest In

wing, with Scer\GAL4^Bx-MS1096

(Lee et al., 2003)

wing disc, with Scer\GAL4^Bx-MS1096

(Lee et al., 2003)

Detailed Description

Statement

Reference

Expression of one copy of by^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096 results in flies with smaller wings that normal that are convex in shape. This phenotype is more severe when two copies of by^Scer\UAS.cLa are overexpressed. Apoptotic cell death in the wing imaginal discs of these animals is dramatically increased compared to wild type.

(Lee et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, by^UAS.cLa has visible phenotype, enhanceable by hep^UAS.cBa/Scer\GAL4^Bx-MS1096

(Lee et al., 2003)

Scer\GAL4^Bx-MS1096, by^UAS.cLa has visible phenotype, enhanceable by bsk^UAS.cBa/Scer\GAL4^Bx-MS1096

(Lee et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, by^UAS.cLa has wing phenotype, enhanceable by hep^UAS.cBa/Scer\GAL4^Bx-MS1096

(Lee et al., 2003)

Scer\GAL4^Bx-MS1096, by^UAS.cLa has wing phenotype, enhanceable by bsk^UAS.cBa/Scer\GAL4^Bx-MS1096

(Lee et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^Bx-MS1096/by^UAS.cLa rescues by²

(Lee et al., 2003)

Comments

Expression of by^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096 dramatically rescues the wing blister phenotype of by² homozygotes.

(Lee et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

by^Scer\UAS.cLa

by^UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Lee

(Lee et al., 2003)

Secondary FlyBase IDs

References (1)

Report Sections

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