FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SCARunspecified
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General Information
Symbol
Dmel\SCARunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0152230
Feature type
allele
Associated gene
Dmel\SCAR
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        SCARunspecified mutant third instar larvae display severe photoreceptor axon targeting defects in the visual system.

        Somatic clones of SCARunspecified induce non-cell-autonomous axon targeting defects in third instar larvae.

        (Stephan et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        SCAR[+]/SCARunspecified is a suppressor of larval ventral nerve cord commissure phenotype of HemC3-20

        (Bogdan and Klambt, 2003)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        SCARunspecified is rescued by Scer\GAL4elav-C155/SCARUASp.cZa

        (Stephan et al., 2011)
        Partially rescued by

        SCARunspecified is partially rescued by Scer\GAL4elav-C155/SCARΔB.UAS

        (Stephan et al., 2011)

        SCARunspecified is partially rescued by Scer\GAL4elav-C155/SCARΔB.ΔP.UAS

        (Stephan et al., 2011)
        Not rescued by

        SCARunspecified is not rescued by SCARUASp.cZa/Scer\GAL4GMR.PU

        (Stephan et al., 2011)

        SCARunspecified is not rescued by Scer\GAL4repo/SCARUASp.cZa

        (Stephan et al., 2011)

        SCARunspecified is not rescued by Scer\GAL4elav-C155/SCARΔN.UAS

        (Stephan et al., 2011)

        SCARunspecified is not rescued by Scer\GAL4elav-C155/SCARΔVCA.UAS

        (Stephan et al., 2011)
        Comments

        Expression of SCARScer\UAS.P\T.cZa in neurons under the control of Scer\GAL4elav-C155 completely restores the axonal projections in SCARunspecified mutant brains.

        Expression of SCARScer\UAS.P\T.cZa in glia cell under the control of Scer\GAL4repo fails to restores the axonal projections in SCARunspecified mutant brains.

        Expression of SCARΔN.Scer\UAS under the control of Scer\GAL4elav-C155 in the neurons of SCARunspecified mutants fails to restore the axonal targeting defects in the visual system.

        SCARΔB.Scer\UAS shows strongly reduced neuronal rescue activities when expressed under the control of Scer\GAL4elav-C155 in SCARunspecified mutants.

        Pan-neuronal expression of SCARΔVCA.Scer\UAS under the control of Scer\GAL4elav-C155 fails to rescue the neuronal phenotypes in the visual system of SCARunspecified mutants.

        Eye disc specific expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4GMR.PU fails to rescue the axonal targeting defects in the visual system of SCARunspecified mutants.

        (Stephan et al., 2011)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        SCARunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (3)