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General Information
Symbol
Dmel\SCARUASp.cZa
Species
D. melanogaster
Name
FlyBase ID
FBal0150643
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-SCAR, UAS-WAVE
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of full length SCAR cDNA (SD02991) is under the control of UASp regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4OK107 does not result in axon growth defects in the mushroom body.

Overexpression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4elav-C155 does not result in any defects in the overall morphology of the embryonic nervous system.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Suppressor of
NOT Suppressor of
Statement
Reference

SCARUASp.cZa, Scer\GAL4elav-C155 is a non-suppressor of neuromuscular junction & synapse phenotype of Fmr1EP3517, Scer\GAL4elav-C155

Additional Comments
Genetic Interactions
Statement
Reference

Pan-neuronal expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4elav-C155 weakly suppresses the AbiΔ20-dependent deficits in axonal targeting.

Expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4sca.PU suppresses the RP2 neuron migration defects seen in HemJ4-48 mutant embryos.

The reduced synaptic length seen at the neuromuscular junction in larvae expressing Fmr1EP3517 under the control of Scer\GAL4elav-C155 is not suppressed by co-expression of SCARScer\UAS.P\T.cZa.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of SCARScer\UAS.P\T.cZa in neurons under the control of Scer\GAL4elav-C155 completely restores the axonal projections in SCARunspecified mutant brains.

Expression of SCARScer\UAS.P\T.cZa in glia cell under the control of Scer\GAL4repo fails to restores the axonal projections in SCARunspecified mutant brains.

Eye disc specific expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4GMR.PU fails to rescue the axonal targeting defects in the visual system of SCARunspecified mutants.

The reduced synaptic length seen at the neuromuscular junction of SCARΔ37/+ larvae is rescued by expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4elav-C155.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
SCARScer\UAS.P\T.cZa
SCARUASp.cZa
Name Synonyms
Secondary FlyBase IDs
    References (7)