FB2026_02 , released June 18, 2026
Allele: Dmel\Ras85D2F4
Open Close
General Information
Symbol
Dmel\Ras85D2F4
Species
D. melanogaster
Name
FlyBase ID
FBal0152257
Feature type
allele
Associated gene
Dmel\Ras85D
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Strutt and Strutt, 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: A59T.

(Strutt and Strutt, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,511,961..9,511,961 [-]
Nucleotide change:

G9511961A

Amino acid change:

A59T | Ras85D-PA

Reported amino acid change:

A59T

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Strutt and Strutt, 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous adult eyes have ommatidial clusters with extra R7 cells, occasionally an extra outer photoreceptor is seen. 1-5% of clusters are misrotated. Homozygotes have occasional defects in R cell specification, and up to 20% clusters are misrotated. The extra R7 phenotype is no stronger than seen in heterozygotes. The adult eyes of Ras85D2F4/Ras85De2F transheterozygotes have some clusters that are missing one or more photoreceptors. Misrotation of clusters is not seen.

      (Strutt and Strutt, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Ras85D2F4 is an enhancer of abnormal cell polarity phenotype of fz20/fz19

      (Strutt and Strutt, 2003)
      Suppressor of
      Statement
      Reference

      Ras85D2F4 is a suppressor of abnormal cell polarity phenotype of Ras64BV14.Act5C

      (Strutt and Strutt, 2003)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Ras85D2F4 is an enhancer of ommatidium phenotype of fz20/fz19

      (Strutt and Strutt, 2003)
      Suppressor of
      Statement
      Reference

      Ras85D2F4 is a suppressor of ommatidium phenotype of Ras64BV14.Act5C

      (Strutt and Strutt, 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of Ras85D2F4/+ enhances the eye cell polarity phenotype seen in fz19/fz20 animals. Heterozygotes suppress the ommatidial polarity defects seen in Ras64BV14.Act5C.

      (Strutt and Strutt, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ras85D2F4
      Name Synonyms
      Secondary FlyBase IDs
        References (2)