FlyBase Allele Report: Dmel\Ask1[K618M.UAS]

General Information

Symbol

Dmel\Ask1^K618M.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0152301

Feature type

allele

Associated gene

Dmel\Ask1

Associated Insertion(s)

Carried in Construct

P{UAS-Ask1.K618M}

Also Known As

UAS-ASK1^DN

Key Links

Transgenic product class

missense_variant

(Kuranaga et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Kuranaga et al., 2002)

Mutagen

in vitro construct

(Kuranaga et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-Ask1.K618M}

Cytology

Description

Expression of kinase dead Ask1 (carries the amino acid replacement K618M) is driven by UASt sequences.

(Kuranaga et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Ask1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Overexpression of Pk92B^{K618M.Scer\UAS}, under the regulation of Scer\GAL4^ap-md544 has no effect on thorax closure.

(Cha et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Ask1^K618M.UAS, Scer\GAL4^dpp.blk1 is a non-suppressor of visible phenotype of Moe^{RNAi.327-775.UAS}, Scer\GAL4^dpp.blk1, puc^E69/puc[+]

(Neisch et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

Ask1^K618M.UAS, Scer\GAL4^ap-md544 is an enhancer of adult thorax phenotype of Scer\GAL4^ap-md544, park^UAS.Tag:MYC

(Cha et al., 2005)

Ask1^K618M.UAS, Scer\GAL4^ap-md544 is an enhancer of mesothoracic cleft | ectopic phenotype of Scer\GAL4^ap-md544, park^UAS.Tag:MYC

(Cha et al., 2005)

Suppressor of

Statement

Reference

Ask1^K618M.UAS, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, rpr^UAS.cIa

(Kuranaga et al., 2002)

NOT Suppressor of

Statement

Reference

Ask1^K618M.UAS, Scer\GAL4^dpp.blk1 is a non-suppressor of wing blade phenotype of Moe^{RNAi.327-775.UAS}, Scer\GAL4^dpp.blk1, puc^E69/puc[+]

(Neisch et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Pk92B^{K618M.Scer\UAS} has no effect on the Scer\GAL4^dpp.blk1>Moe^{dsRNA.327-775.Scer\UAS}; puc^E69/+ wing blade phenotype.

(Neisch et al., 2010)

The thoracic cleft formation observed in park^{Scer\UAS.T:Hsap\MYC} overexpression mutants (Scer\GAL4^ap-md544) is enhanced by co-expression of Pk92B^{K618M.Scer\UAS}.

(Cha et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

99489

w^*; P{UAS-Ask1.K618M}2/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ask1^{K618M.Scer\UAS}

Ask1^K618M.UAS

Pk92B^{K618M.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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