FlyBase Allele Report: Dmel\Mkp3[2]

General Information

Symbol

Dmel\Mkp3²

Species

D. melanogaster

Name

FlyBase ID

FBal0152425

Feature type

allele

Associated gene

Dmel\Mkp3

Associated Insertion(s)

P{EP}Mkp3²

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Rintelen et al., 2003)

Mutagen

Delta2-3 transposase

(Rintelen et al., 2003)

Progenitor genotype

P{EP}MESR6^EP3142

(Rintelen et al., 2003)

Associated Insertion(s)

P{EP}Mkp3²

Cytology

Description

Mobilisation of the P{EP}MESR6^EP3142 element, resulting in a P{EP} insertion in the 5' UTR of Mkp3, 128bp upstream of the Mkp3 ATG codon, with the P{EP} element inserted such that overexpression from the P{EP} element results in overexpression of Mkp3. The progenitor P{EP}MESR6^EP3142 insertion is also still present on the chromosome.

(Rintelen et al., 2003)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:19,085,851..19,085,851 [-]

(Rintelen et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile (with Mkp3¹)

(Rintelen et al., 2003)

viable (with Mkp3¹)

(Rintelen et al., 2003)

visible, with Scer\GAL4^hs.2sev

(Rintelen et al., 2003)

visible (with Mkp3¹)

(Rintelen et al., 2003)

Phenotype Manifest In

eye, with Scer\GAL4^hs.2sev

(Rintelen et al., 2003)

eye photoreceptor cell | increased number (with Mkp3¹)

(Rintelen et al., 2003)

photoreceptor cell R3 (with Mkp3¹)

(Rintelen et al., 2003)

photoreceptor cell R4 (with Mkp3¹)

(Rintelen et al., 2003)

photoreceptor cell R7 | increased number (with Mkp3¹)

(Rintelen et al., 2003)

wing vein | increased number (with Mkp3¹)

(Rintelen et al., 2003)

Detailed Description

Statement

Reference

Overexpression of Mkp3² under the control of Scer\GAL4^hs.2sev results in a rough eye phenotype. Mkp3¹/Mkp3² flies have additional vein material in the wing. R3 and R4 photoreceptor cells are often symmetrically arranged in Mkp3¹/Mkp3² ommatidia. These symmetrical ommatidia sometimes also contain an extra R7 or extra outer photoreceptor cell. The additional cell always invades the ommatidium between the R3 and R4 cells.

(Rintelen et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Mkp3¹/Mkp3² has visible phenotype, enhanceable by Egfr^E3/Egfr[+]

(Rintelen et al., 2003)

Mkp3¹/Mkp3² has visible phenotype, enhanceable by PTP-ER[+]/PTP-ER^XE-3022

(Rintelen et al., 2003)

Suppressed by

Statement

Reference

Mkp3¹/Mkp3² has visible phenotype, suppressible by rl[+]/rl^10a

(Rintelen et al., 2003)

Other

Statement

Reference

Mkp3¹/Mkp3², PTP-ER^XE-3022 has lethal | pharate adult stage phenotype

(Rintelen et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Mkp3¹/Mkp3² has wing vein | increased number phenotype, enhanceable by Egfr^E3/Egfr[+]

(Rintelen et al., 2003)

Mkp3¹/Mkp3² has wing vein | increased number phenotype, enhanceable by PTP-ER[+]/PTP-ER^XE-3022

(Rintelen et al., 2003)

Suppressed by

Statement

Reference

Mkp3¹/Mkp3² has eye photoreceptor cell phenotype, suppressible by rl[+]/rl^10a

(Rintelen et al., 2003)

Mkp3¹/Mkp3² has wing vein | increased number phenotype, suppressible by rl[+]/rl^10a

(Rintelen et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The Mkp3¹/Mkp3² eye phenotype is almost completely suppressed by rl^10a/+. PTP-ER^XE-3022 ; Mkp3¹/Mkp3² pharate adults have ommatidia characteristic of either single mutant.

(Rintelen et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dmkp3²

(Rintelen et al., 2003)

Mkp3²

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close