FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cnx99AEP3522
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General Information
Symbol
Dmel\Cnx99AEP3522
Species
D. melanogaster
Name
FlyBase ID
FBal0152675
Feature type
allele
Associated gene
Dmel\Cnx99A
Associated Insertion(s)
P{EP}Cnx99AEP3522
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(McGovern et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{EP}Cnx99AEP3522
Cytology
Description

Inserted 800bp upstream of the start of the first Cnx99A exon.

(McGovern et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ventral nerve cord commissures in stage 17 Cnx99AEP3522; Scer\GAL4sca-4512 embryos are fused and/or 'fuzzy'.The two most medial 1D4 longitudinal fascicles cross and recross the midline. Marker assays suggest some cell fate changes among ventral nerve cord cells. Similar defects in ventral nerve cord commissures and ventral nerve cord cell fate are seen in Cnx99AEP3522; Scer\GAL4sim.PS embryos, but only the most medial 1D4 longitudinal fascicle crosses the midline.

      (McGovern et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Cnx99AEP3522 enhances the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      Co-expression of Cnx99AEP3522 with kayFbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 partially suppresses the small synapse phenotype found in kayFbz.Scer\UAS mutants.

      (Franciscovich et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Cnx99AEP3522
      Name Synonyms
      Secondary FlyBase IDs
        References (2)