FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Alk::HsapNPM1UAS.act
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General Information
Symbol
Dmel\Alk::Hsap\NPM1UAS.act
Species
D. melanogaster
Name
FlyBase ID
FBal0152789
Feature type
allele
Associated gene
Alk::Hsap\NPM1
Associated Insertion(s)
Carried in Construct
P{UAS-NPM:Alk}
Also Known As
UAS-Alkact
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Lee et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-NPM:Alk}
Cytology
Description

Expression of codons 1-117 of Hsap\NPM1 fused to codons 1129-1701 of Alk, is under the control of UASt sequences.

(Lee et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Alk::Hsap\NPM1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTGMR.Ex.PJ
      (Park et al., 2021)
      modeled by Hsap\MAPTUAS.cWa
      (Park et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neuromuscular junction terminals are compacted into a smaller area than normal in third instar larvae expressing AlkScer\UAS.T:Hsap\NPM1 under the control of Scer\GAL4C57.

      (Rohrbough et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      Statement
      Reference

      Scer\GAL4bap.3/Alk::Hsap\NPM1UAS.act is a suppressor of muscle founder cell & visceral mesoderm phenotype of jeb-c1

      (Lee et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Loss of visceral muscle founder cells in jeb-c1 mutant embryos, is suppressed by AlkScer\UAS.T:Hsap\NPM1.

      (Lee et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference

      The rough eye induced by Hsap\MAPTGMR.Ex.PJ is enhanced by the expression of Alk::Hsap\NPM1UAS.act under the control of Scer\GAL4GMR.PU, leading to reduced retina thickness and marked neuronal loss.

      (Park et al., 2021)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Alk::Hsap\NMP1Scer\UAS.act
      Alk::Hsap\NMP1UAS.act
      Alk::Hsap\NPM1UAS.act
      AlkScer\UAS.T:Hsap\NPM1
      Name Synonyms
      Secondary FlyBase IDs
        References (5)