FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sraEY07182
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General Information
Symbol
Dmel\sraEY07182
Species
D. melanogaster
Name
FlyBase ID
FBal0154478
Feature type
allele
Associated gene
Dmel\sra
Associated Insertion(s)
P{EPgy2}sraEY07182
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}sraEY07182
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Lee et al., 2016)
      modeled by Hsap\APPAβ42.UAS.cBa
      (Lee et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of sraEY07182 under the control of Scer\GAL4GMR.PU results in a mild rough-eye phenotype compared to controls and neurodegeneration of photoreceptor neurons in larval eye disc as well as photoreceptor axon targeting defects in third instar larval brain are observed.

      Expression of sraEY07182 under the control of Scer\GAL4elav.PU results in significantly decreased survival rate during development as well as shorter adult life-span of the survivors but has not affect on climbing abilities of the adults compared to controls. Adult flies also display reduced survival rate under oxidative stress conditions compared to controls. The level of cell death is significantly increased in sraEY07182 expressing third instar larval brains as is the number of brain glial cells.

      (Lee et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Enhancer of
      NOT Enhancer of
      Suppressor of
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Enhancer of
      NOT Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mild rough-eye phenotype characteristic for flies expressing sraEY07182 under the control of Scer\GAL4GMR.PU is suppressed by co-expression of Diap1Scer\UAS.cHa.

      (Lee et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference

      The severe rough eye phenotype in adults as well as the increased levels of cell death in the larval eye disc observed in flies expressing Hsap\APPAβ42.Scer\UAS.cBa under the control of Scer\GAL4GMR.PU are exacerbated further by co-expression of sraEY07182.

      The increased mortality during development as well as the reduced climbing abilities of adults characteristic for flies expressing Hsap\APPAβ42.Scer\UAS under the control of Scer\GAL4elav.PU are aggravated further by co-expression of sraEY07182.

      The decreased adult life-span observed both in flies expressing sraEY07182 or Hsap\APPAβ42.Scer\UAS under the control of Scer\GAL4elav.PU is reduced further when the two transgenes are co-expressed.

      The high level of cell death in third instar larval brain as well as the reduced adult survival rate under oxidative stress conditions seen in flies expressing either Hsap\APPAβ42.Scer\UAS or sraEY07182 under the control of Scer\GAL4elav.PU are aggravated further when the two transgenes are expressed simultaneously.

      The neurodegeneration of photoreceptor neurons in larval eye disc as well as the photoreceptor axon targeting defects in the brain observed in larvae expressing either Hsap\APPAβ42.Scer\UAS or sraEY07182 under the control of Scer\GAL4GMR.PU are significantly enhanced when the two transgenes are co-expressed.

      The increased number of glial cells in third instar larval brain observed in larvae expressing either Hsap\APPAβ42.Scer\UAS or sraEY07182 under the control of Scer\GAL4elav.PU does not increase further when Hsap\APPAβ42.Scer\UAS and sraEY07182 are co-expressed.

      The increased mortality during development characteristic for adult flies expressing Hsap\APP695.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav.PU is improved by co-expression of sraEY07182.

      (Lee et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sraEY07182
      (Lee et al., 2016)
      sraEY
      (Lee et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)