FlyBase Allele Report: Dmel\sgg[EY02862]

General Information

Symbol

Dmel\sgg^EY02862

Species

D. melanogaster

Name

FlyBase ID

FBal0154627

Feature type

allele

Associated gene

Dmel\sgg

Associated Insertion(s)

P{EPgy2}sgg^EY02862

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}sgg^EY02862

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:2,658,712..2,658,712 [+]

(Franciscovich et al., 2008, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

abnormal neurophysiology, with Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

abnormal neurophysiology, with Scer\GAL4^RapGAP1-OK6

(Franciscovich et al., 2008)

Phenotype Manifest In

synapse, with Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Detailed Description

Statement

Reference

Expression of sgg^EY02862 in differentiated post-mitotic neurons under the control of Scer\GAL4^elav-C155 suppresses synaptic growth.

Expression of sgg^EY02862 under the control of Scer\GAL4^OK6 significantly reduces EJC amplitude compared to controls.

(Franciscovich et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^elav-C155, sgg^EY02862 has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^elav-C155/kay^Fbz.UAS

(Franciscovich et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^elav-C155, sgg^EY02862 has abnormal neuroanatomy phenotype, suppressible by Jra^UAS.cEa/kay^UAS.cEa, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Suppressor of

Statement

Reference

sgg^EY02862, Scer\GAL4^elav-C155 is a suppressor of abnormal neurophysiology phenotype of Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa

(Franciscovich et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^elav-C155, sgg^EY02862 has synapse phenotype, enhanceable by Scer\GAL4^elav-C155/kay^Fbz.UAS

(Franciscovich et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^elav-C155, sgg^EY02862 has synapse phenotype, suppressible by Jra^UAS.cEa/kay^UAS.cEa, Scer\GAL4^elav-C155

(Franciscovich et al., 2008)

Enhancer of

Statement

Reference

Scer\GAL4^elav-C155/sgg^EY02862 is an enhancer of synapse phenotype of Scer\GAL4^elav-C155, kay^Fbz.UAS

(Franciscovich et al., 2008)

Suppressor of

Statement

Reference

sgg^EY02862, Scer\GAL4^elav-C155 is a suppressor of synapse phenotype of Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^UAS.cEa

(Franciscovich et al., 2008)

sgg^EY02862, Scer\GAL4^elav-C155 is a suppressor of synapse phenotype of Jra^UAS.cEa, Scer\GAL4^elav-C155, kay^Fbz.UAS

(Franciscovich et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of sgg^EY02862 in a kay^Scer\UAS.cEa Jra^Scer\UAS.cEa over-expression background (all under the control of Scer\GAL4^elav-C155) results in synapses that are similar to wild-type.

Co-expression of sgg^EY02862 with kay^Fbz.Scer\UAS in differentiated post-mitotic neurons under the control of Scer\GAL4^elav-C155 enhances the small synapse phenotype found in kay^Fbz.Scer\UAS mutants.

(Franciscovich et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

15886

y¹ P{EPgy2}sgg^EY02862 w^67c23

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sgg^EY02862

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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