FB2026_02 , released June 18, 2026
Allele: Dmel\GenZ4325
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General Information
Symbol
Dmel\GenZ4325
Species
D. melanogaster
Name
FlyBase ID
FBal0154853
Feature type
allele
Associated gene
Dmel\Gen
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Laurencon et al., 2004)
Progenitor genotype
Cytology
Description

Deletion of ATATAC and insertion of a single G, creating a frameshift at codons 374-375 (within the conserved nuclease domain).

(Andersen et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:5,150,922..5,150,927 [-]
(Andersen et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mus324ZIII-4325/mus324ZIII-5997 mutants have a similar frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 38oC, but show a reduced SSA frequency compared to controls when assayed at 32oC.

      (Wei and Rong, 2007)

      Mutant larvae are sensitive to nitrogen mustard and to methyl methanesulfonate (compared to control larvae).

      (Laurencon et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      WRNexoΔ/WRNexoΔ GenZ4325/GenZ4325 double mutants survive to pupal stage.

      (Bolterstein et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      The GenZ4325 and GenZ5997 alleles contain identical mutations, thus they may be two isolates of the same mutational event.

      (Andersen et al., 2011)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Gen4325
      (Andersen et al., 2011)
      GenZ4325
      (Bolterstein et al., 2014, Andersen et al., 2011)
      mus324Z4325
      (Andersen et al., 2011)
      mus324ZIII-4325
      mus324ZIII4325
      (Wei and Rong, 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)