FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mbf1+t4574
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General Information
Symbol
Dmel\mbf1+t4574
Species
D. melanogaster
Name
FlyBase ID
FBal0155018
Feature type
allele
Associated gene
Dmel\mbf1
Associated Insertion(s)
Carried in Construct
P{mbf1+t4574}
Key Links
Genomic Maps

Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Liu et al., 2003)
Progenitor genotype
Carried in construct
P{mbf1+t4574}
Cytology
Description

4574 bp of mbf1 genomic sequence.

(Liu et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
mbf1
Encoded product / tool
mbf1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3L:16,571,970..16,576,904 [+]
Linked to:
EcoRI-EcoRI restriction fragment
Comment:

The rescue fragment is described as a 4574bp genomic EcoRI fragment. The annotated rescue fragment is 361 bases larger due to a 361bp tandem repeat in the genomic sequence, which begins roughly 2.3kb upstream of mbf1.

(Liu et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults carrying two copies of mbf1+t4574 in a wild-type background are show increased resistance to hydrogen peroxide.

      (Jindra et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      mbf1[+], mbf12, mbf1+t4574 is a non-enhancer of sex comb tooth | ectopic phenotype of Psc1

      (Nishioka et al., 2018)

      mbf1[+], mbf12, mbf1+t4574 is a non-enhancer of sex comb tooth | ectopic phenotype of Pc6

      (Nishioka et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ectopic sex comb teeth phenotype of Psc1 or Pc6 heterozygous males is exacerbated by mbf12 heterozygosity; these phenotype enhancements are annulled by one copy of mbf1+t4574.

      (Nishioka et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      mbf1+t4574 rescues mbf12

      (Jindra et al., 2004)
      Comments

      mbf1+t4574/mbf1+t4574 part rescues the CNS and tracheal phenotypes of apttdf-PΔ3/+; mbf12/mbf12 embryos.

      (Liu et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mbf1+t4574
      Name Synonyms
      Secondary FlyBase IDs
        References (3)