FlyBase Allele Report: Dmel\Pc[6]

General Information

Symbol

Dmel\Pc⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0013556

Feature type

allele

Associated gene

Dmel\Pc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

non-enhancer of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

non-suppressor of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

Phenotype Manifest In

mesothoracic leg

(Lindsley and Zimm, 1992)

mesothoracic leg & sex comb tooth | ectopic

(Ragab, 2006)

metathoracic leg

(Lindsley and Zimm, 1992)

metathoracic leg & sex comb tooth | ectopic

(Ragab, 2006)

sex comb | ectopic

(Schaaf et al., 2013)

sex comb tooth | ectopic

(Nishioka et al., 2018)

Detailed Description

Statement

Reference

Pc⁶ dominantly leads to ectopic sex comb teeth on the second leg of males, as compared to controls.

(Nishioka et al., 2018)

Pc⁶ males have ectopic sex combs on the second and third leg.

(Ragab, 2006)

Partial transformations of second and third legs into first legs in Pc/+ heterozygotes.

(Lindsley and Zimm, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Pc[+]/Pc⁶ is an enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Pc[+]/Pc⁶ is an enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Other

Statement

Reference

Pc⁶, P{hsp26-pt-T}39C-5, ph-p⁴¹⁰ has suppressor of variegation phenotype

(Boivin et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pc⁶ has sex comb tooth | ectopic phenotype, enhanceable by mbf1[+]/mbf1²

(Nishioka et al., 2018)

Pc⁶ has sex comb tooth | ectopic phenotype, enhanceable by pcm^hs.PG/mbf1[+]/mbf1², pcm^Δ1/pcm^Δ1

(Nishioka et al., 2018)

Pc⁶ has sex comb | ectopic phenotype, enhanceable by pds5^e3

(Schaaf et al., 2013)

Pc⁶ has sex comb | ectopic phenotype, enhanceable by pds5^e6

(Schaaf et al., 2013)

NOT Enhanced by

Statement

Reference

Pc⁶ has sex comb tooth | ectopic phenotype, non-enhanceable by mbf1[+]/mbf1²/mbf1^+t4574

(Nishioka et al., 2018)

Suppressed by

Statement

Reference

Pc⁶ has sex comb tooth | ectopic phenotype, suppressible by pcm^Δ1/pcm^Δ1

(Nishioka et al., 2018)

Pc⁶ has sex comb | ectopic phenotype, suppressible by vtd⁶

(Schaaf et al., 2013)

Pc⁶ has sex comb | ectopic phenotype, suppressible by vtd^80Fh-36

(Schaaf et al., 2013)

Pc⁶ has sex comb | ectopic phenotype, suppressible by Nipped-B⁴⁰⁷

(Schaaf et al., 2013)

NOT suppressed by

Statement

Reference

Pc⁶ has sex comb tooth | ectopic phenotype, non-suppressible by pcm^hs.PG, pcm^Δ1/pcm^Δ1

(Nishioka et al., 2018)

Pc⁶ has sex comb tooth | ectopic phenotype, non-suppressible by mbf1[+]/mbf1², pcm^Δ1/pcm^Δ1

(Nishioka et al., 2018)

Pc⁶ has sex comb | ectopic phenotype, non-suppressible by SMC1^exc46

(Schaaf et al., 2013)

Pc⁶ has mesothoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Pc⁶ has metathoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Enhancer of

Statement

Reference

Pc[+]/Pc⁶ is an enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Pc[+]/Pc⁶ is an enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

NOT Enhancer of

Statement

Reference

Pc⁶ is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2002)

NOT Suppressor of

Statement

Reference

Pc⁶ is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic sex comb teeth phenotype of Pc⁶ heterozygous males is partially suppressed by homozygosity for pcm^Δ1 and is exacerbated by heterozygosity for mbf1²; the phenotype enhancement by mbf1² heterozygosity is annulled by one copy of mbf1^+t4574; the phenotype suppression by pcm^Δ1 homozygosity is annulled either by heterozygosity for mbf1² or by the heat-shock-induced expression of pcm^hs.PG. The ectopic sex comb teeth phenotype of Pc⁶ heterozygous males is also exacerbated by the triple combination of mbf1² heterozygosity, pcm^Δ1 homozygosity and heat-shock-induced expression of pcm^hs.PG.

(Nishioka et al., 2018)

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is exacerbated by combination with a single copy of Pc⁶.

(Morimoto et al., 2016)

Df(2R)ED3921 fails to suppress the ectopic sex comb phenotype of Pc⁶ mutants.

(Ragab, 2006)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is exacerbated by combination with a single copy of Pc⁶.

(Morimoto et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

107755

ru¹ hry¹ Diap1^th-1 st¹ Pc⁶ cu¹ sr¹ e^s ca¹/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pc⁶

(Nishioka et al., 2018, Morimoto et al., 2016)

Pc^9M21

(Weigmann and Lehner, 1995)

Pc^9M

(Tearle and Nusslein-Volhard, 1987)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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