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General Information
Symbol
Dmel\Pc6
Species
D. melanogaster
Name
FlyBase ID
FBal0013556
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Pc6 dominantly leads to ectopic sex comb teeth on the second leg of males, as compared to controls.

Pc6 males have ectopic sex combs on the second and third leg.

Partial transformations of second and third legs into first legs in Pc/+ heterozygotes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference

Pc6 has sex comb tooth | ectopic phenotype, enhanceable by mbf1[+]/mbf12

Pc6 has sex comb tooth | ectopic phenotype, enhanceable by pcmhs.PG/mbf1[+]/mbf12, pcmΔ1/pcmΔ1

Pc6 has sex comb | ectopic phenotype, enhanceable by pds5e3

Pc6 has sex comb | ectopic phenotype, enhanceable by pds5e6

NOT Enhanced by
Statement
Reference

Pc6 has sex comb tooth | ectopic phenotype, non-enhanceable by mbf1[+]/mbf12/mbf1+t4574

Suppressed by
Statement
Reference

Pc6 has sex comb | ectopic phenotype, suppressible | partially by vtd6

Pc6 has sex comb | ectopic phenotype, suppressible by vtd80Fh-36

Pc6 has sex comb | ectopic phenotype, suppressible by Nipped-B407

NOT suppressed by
Statement
Reference

Pc6 has sex comb tooth | ectopic phenotype, non-suppressible by pcmhs.PG, pcmΔ1/pcmΔ1

Pc6 has sex comb tooth | ectopic phenotype, non-suppressible by mbf1[+]/mbf12, pcmΔ1/pcmΔ1

Pc6 has sex comb | ectopic phenotype, non-suppressible by SMC1exc46

Pc6 has mesothoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

Pc6 has metathoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

Pc6 is a non-enhancer of eye phenotype of CycEJP

NOT Suppressor of
Statement
Reference

Pc6 is a non-suppressor of eye phenotype of CycEJP

Additional Comments
Genetic Interactions
Statement
Reference

The ectopic sex comb teeth phenotype of Pc6 heterozygous males is partially suppressed by homozygosity for pcmΔ1 and is exacerbated by heterozygosity for mbf12; the phenotype enhancement by mbf12 heterozygosity is annulled by one copy of mbf1+t4574; the phenotype suppression by pcmΔ1 homozygosity is annulled either by heterozygosity for mbf12 or by the heat-shock-induced expression of pcmhs.PG. The ectopic sex comb teeth phenotype of Pc6 heterozygous males is also exacerbated by the triple combination of mbf12 heterozygosity, pcmΔ1 homozygosity and heat-shock-induced expression of pcmhs.PG.

The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is exacerbated by combination with a single copy of Pc6.

Df(2R)ED3921 fails to suppress the ectopic sex comb phenotype of Pc6 mutants.

Xenogenetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is exacerbated by combination with a single copy of Pc6.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)