FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eveΔEL
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General Information
Symbol
Dmel\eveΔEL
Species
D. melanogaster
Name
FlyBase ID
FBal0155323
Feature type
allele
Associated gene
Dmel\eve
Associated Insertion(s)
Carried in Construct
P{eve.ΔEL}
Also Known As
ΔEL
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Fujioka et al., 2003)
Progenitor genotype
eveE+L.9.2
(Fujioka et al., 2003)
Carried in construct
P{eve.ΔEL}
Cytology
Description

Sequence from +1.9kb to +2.6kb (coordinates relative to the eve transcription start site) of the eve genomic region has been deleted, thus sequences from -6.4kb to +1.9kb and from +2.6kb to +9.2kb of eve are present.

(Fujioka et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
eve
Encoded product / tool
eve
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In eveΔEL/eveΔEL, Df(2R)eve/Df(2R)eve, stage 16 embryos, EL interneuron axons cross the midline normally but an increased proportion extend along both the intermediate and medial fascicles and some even project along the the intermediate and lateral fascicles. In stage 17 embryos, only a small proportion of EL interneuron axons reach the next segment.

      In eveΔEL/eveΔEL, Df(2R)eve/Df(2R)eve and eveΔEL/eveΔEL, eve3/eve3 larvae, EL interneurons branch excessively off the main neurite near the soma and in the midline, which is never seen in controls; the axon is less extended than in controls, branching at ~40 microns from the soma; the dorsally projecting dendrites are significantly reduced and the ventrally projecting dendrites are significant increased. These eveΔEL/eveΔEL, Df(2R)eve/Df(2R)eve El interneurons fail to show a response to vibration/sound stimuli; their presynaptic nerve termini are found throughout the neuropile, rather than concentrated in the medial and intermediate zones.

      eveΔEL/eveΔEL, Df(2R)eve/Df(2R)eve and eveΔEL/eveΔEL, Df(2R)eve/eve3 larvae show decreased crawling ability. eveΔEL/eveΔEL, Df(2R)eve/Df(2R)eve larvae show left-right asymmetrical body posture.

      (Marshall and Heckscher, 2022)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eveΔEL
      ΔEL
      (Lacin et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)