FlyBase Allele Report: Dmel\ed[ts]

General Information

Symbol

Dmel\ed^ts

Species

D. melanogaster

Name

FlyBase ID

FBal0155338

Feature type

allele

Associated gene

Dmel\ed

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ahmed et al., 2003)

Progenitor genotype

Cytology

Description

Amino acid replacement: D610N. Nucleotide substitution: G1834A.

(Ahmed et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:4,098,932..4,098,932 [+]

Nucleotide change:

G4098932A

Reported nucleotide change:

G1834A

Amino acid change:

D612N | ed-PA; D612N | ed-PB; D612N | ed-PC

Reported amino acid change:

D610N

(Ahmed et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with ed^2B8)

(Ahmed et al., 2003)

lethal | heat sensitive (with ed^2B8)

(Ahmed et al., 2003)

viable

(Ahmed et al., 2003)

visible (with ed^m1)

(Ahmed et al., 2003)

Phenotype Manifest In

eye (with ed^2B8)

(Ahmed et al., 2003)

eye (with ed^m1)

(Ahmed et al., 2003)

larval ventral nerve cord (with ed^2B8)

(Ahmed et al., 2003)

macrochaeta | ectopic (with ed^2B8)

(Ahmed et al., 2003)

macrochaeta | ectopic (with ed^m1)

(Ahmed et al., 2003)

microchaeta (with ed^2B8)

(Ahmed et al., 2003)

microchaeta (with ed^m1)

(Ahmed et al., 2003)

presumptive embryonic/larval central nervous system (with ed^2B8)

(Ahmed et al., 2003)

wing margin | distal (with ed^2B8)

(Ahmed et al., 2003)

wing vein L2 (with ed^2B8)

(Ahmed et al., 2003)

wing vein L2 (with ed^m1)

(Ahmed et al., 2003)

Detailed Description

Statement

Reference

Viable as a homozygote or transheterozygous to another ed allele up to 25^oC, but embryonic lethal with ed^2B8 at 29^oC. ed^2B8/ed^ts embryos grown at the restrictive temperature of 29^oC show hyperplasia of the central nervous system, resulting in local bulging of the ventral nerve cord. ed^2B8/ed^ts and ed^m1/ed^ts animals shifted to the non-permissive temperature (29^oC) for 3 days at the end of larval stage 2 and then shifted back to 18^oC can survive to adulthood. These flies have extra macrochaetae, which are generally found next to macrochaetae that are normally present in wild-type flies. The density of microchaetae is also increased and the flies have a rough eye phenotype. ed^2B8/ed^ts adult escapers (shifted to the non-permissive temperature for 3 days at the end of larval stage 2 and then raised at 18^oC) show irregular thickening of wing vein 2 and/or slight notching of the distal wing margin. ed^m1/ed^ts flies grown at 25^oC have irregular thickenings of wing vein L2. Heterozygotes raised at 29^oC have wild-type wing morphology.

(Ahmed et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ed^m1/ed^ts has visible phenotype, enhanceable by Delta^vi1/Dl[+]

(Ahmed et al., 2003)

Suppressor of

Statement

Reference

ed^ts/ed^2B8 is a suppressor of abnormal neuroanatomy phenotype of N^int.G.UAS, Scer\GAL4^Kr.PM

(Ahmed et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

ed^m1/ed^ts has wing vein L2 phenotype, enhanceable by Delta^vi1/Dl[+]

(Ahmed et al., 2003)

Suppressor of

Statement

Reference

ed^ts/ed^2B8 is a suppressor of larval neuron phenotype of N^int.G.UAS, Scer\GAL4^Kr.PM

(Ahmed et al., 2003)

Other

Statement

Reference

Delta^vi1, ed^m1/ed^ts has wing vein | ectopic phenotype

(Ahmed et al., 2003)

Delta^vi1, ed^m1/ed^ts has posterior wing cell phenotype

(Ahmed et al., 2003)

Delta^vi1/Dl[+], ed^m1/ed^ts has wing vein | ectopic phenotype

(Ahmed et al., 2003)

Delta^vi1/Dl[+], ed^m1/ed^ts has posterior wing cell phenotype

(Ahmed et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of neurons seen in embryos expressing N^{int.G.Scer\UAS} under the control of Scer\GAL4^Kr.PM is suppressed by ed^2B8/ed^ts at 29^oC. The thickening of wing vein L2 seen in ed^m1/ed^ts flies grown at 25^oC is enhanced by Dl^vi1/+, and in addition, extra wing vein material is seen in the posterior cell of the wing. ed^ts/+ enhances the Df(3R)Espl1/+ phenotype; the extra wing vein material is expanded compared to Df(3R)Espl1/+ flies and the phenotype shows full penetrance.

(Ahmed et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ed^ts

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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