FlyBase Allele Report: Dmel\botv[423]

General Information

Symbol

Dmel\botv⁴²³

Species

D. melanogaster

Name

FlyBase ID

FBal0155558

Feature type

allele

Associated gene

Dmel\botv

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Lujan et al., 2016)

Mutagen

ethyl methanesulfonate

(Takei et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: L259term.

(Takei et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:19,130,975..19,130,975 [+]

Nucleotide change:

T19130975R

Amino acid change:

L259term | botv-PA

Reported amino acid change:

L259term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Takei et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Lujan et al., 2016)

lethal (with botv^2R24)

(Lujan et al., 2016)

lethal - all die before end of pupal stage (with botv⁵¹⁰)

(Takei et al., 2004)

some die during pupal stage (with botv⁵¹⁰)

(Takei et al., 2004)

Phenotype Manifest In

embryonic/larval cuticle | embryonic stage | maternal effect

(Lujan et al., 2016)

embryonic/larval cuticle | embryonic stage | maternal effect (with botv^2R24)

(Lujan et al., 2016)

eye | P-stage (with botv⁵¹⁰)

(Takei et al., 2004)

imaginal disc | larval stage (with botv⁵¹⁰)

(Takei et al., 2004)

leg | P-stage (with botv⁵¹⁰)

(Takei et al., 2004)

wing | somatic clone

(Takei et al., 2004)

wing disc | larval stage (with botv⁵¹⁰)

(Takei et al., 2004)

Detailed Description

Statement

Reference

botv⁴²³ homozygotes and botv^2R24/botv⁴²³ transheterozygotes are lethal; botv⁴²³ maternal-zygotic homozygous embryos show severe cuticle defects, including fused denticle belts and loss of naked cuticle, as compared to controls.

(Lujan et al., 2016)

botv⁴²³/botv⁵¹⁰ animals die as pupae with small eyes and legs. Third instar larvae have smaller discs than the wild type, and in particular, their wing discs are narrower in an anterior-posterior direction. Tissue is deleted within somatic clones of botv⁴²³ homozygous cells in the adult wing.

(Takei et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

botv⁴²³

(Reynolds-Peterson et al., 2020, Lujan et al., 2016, Ren et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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