FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\aPKCpsu69
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General Information
Symbol
Dmel\aPKCpsu69
Species
D. melanogaster
Name
FlyBase ID
FBal0155670
Feature type
allele
Associated gene
Dmel\aPKC
Associated Insertion(s)
Carried in Construct
Also Known As
2R-69-30
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Kim et al., 2009)
Mutagen
ethyl methanesulfonate
(Luschnig et al., 2004, Luschnig et al., 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: C122Y.

(Kim et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:14,949,388..14,949,388 [-]
Nucleotide change:

G14949388A

Amino acid change:

C122Y | aPKC-PA; C40Y | aPKC-PB; C122Y | aPKC-PC; C122Y | aPKC-PD; C40Y | aPKC-PE; C19Y | aPKC-PF; C467Y | aPKC-PG; C40Y | aPKC-PI; C474Y | aPKC-PJ; C35Y | aPKC-PK; C19Y | aPKC-PL; C19Y | aPKC-PM

Reported amino acid change:

C122Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kim et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous tracheal terminal cells show a reduction in branching compared to wild type. The mutant cells contain a normal gas-filled lumen running through each branch and show normal branch tip morphology.

      (Jones and Metzstein, 2011)

      Occasional aPKCpsu69/aPKCpsu265 and aPKCpsu69/aPKCpsu417 adult escapers are seen.

      Embryos derived from homozygous female germ-line clones develop only scattered crumbs of cuticle.

      The egg chambers of homozygous females show both multilayering and large gaps in the follicle epithelium.

      Homozygous follicle cell clones show a normal monolayered tissue structure. Gaps are occasionally seen in the follicle cell epithelium.

      (Kim et al., 2009)

      Embryos derived from females carrying homozygous germ line clones produce just small pieces of cuticle and Filzkorper material. Homozygous females lay no eggs.

      (Luschnig et al., 2004)

      Embryos derived from females carrying homozygous germ line clones fail to produce a coherent cuticle.

      (Luschnig et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      2R-69-30
      (Kim et al., 2009, Luschnig et al., 2004)
      aPKC2R-69-30
      aPKCpsu69
      (Nunes de Almeida et al., 2019, Jones and Metzstein, 2011, Kim et al., 2009)
      psu2R-69-30
      (Luschnig et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)