FlyBase Allele Report: Dmel\Pp2A-29B[EP2332]

General Information

Symbol

Dmel\Pp2A-29B^EP2332

Species

D. melanogaster

Name

FlyBase ID

FBal0156058

Feature type

allele

Associated gene

Dmel\Pp2A-29B

Associated Insertion(s)

P{EP}Pp2A-29B^EP2332

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EP}Pp2A-29B^EP2332

Cytology

Description

P{EP} insertion within Pp2A-29B.

(FlyBase, 1996-)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:8,366,028..8,366,028 [+]

(Agrawal and Hardin, 2016, Bánréti et al., 2012, Wang et al., 2011, Oren-Giladi et al., 2008, FlyBase, 1996-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Kotadia et al., 2008)

Phenotype Manifest In

neuroblast (with Pp2A-29B^CB-5426-3)

(Wang et al., 2009)

Detailed Description

Statement

Reference

Starvation induced formation of lysosomes/autolysosomes is blocked in mutant larvae.

(Bánréti et al., 2012)

The mitotic spindle is misaligned with the cortical crescent in some Pp2A-29B^CB-5426-3/Pp2A-29B^EP2332 neuroblasts.

(Wang et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Pp2A-29B^EP2332/Pp2A-29B[+] is an enhancer of lethal | embryonic stage phenotype of SV40\ST^{UASp.Tag:FLAG}, Scer\GAL4^{VP16.nanos.UTR}

(Kotadia et al., 2008)

Suppressor of

Statement

Reference

Pp2A-29B^EP2332/Pp2A-29B[+] is a suppressor | partially of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Phenotype Manifest In

Enhancer of

Statement

Reference

Pp2A-29B^EP2332/Pp2A-29B[+] is an enhancer of centrosome | increased number phenotype of SV40\ST^{UASp.Tag:FLAG}, Scer\GAL4^{VP16.nanos.UTR}

(Kotadia et al., 2008)

Suppressor of

Statement

Reference

Pp2A-29B^EP2332/Pp2A-29B[+] is a suppressor | partially of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Pp2A-29B^EP2332/Pp2A-29B[+] is a suppressor | partially of developing neuron | larval stage | decreased number | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

The embryos resulting from the cross between polo¹¹/+, Pp2A-29B^EP2332/+ mothers and wild-type fathers hatch at wild-type rates.

(Wang et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

17044

w¹¹¹⁸; P{EP}Pp2A-29B^EP2332/CyO

Kyoto

114447

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{EP}Pp2A-29B^EP2332 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PP2A-29B^EP2332

(Zhang et al., 2024)

PP2A-29B^EP

(Wang et al., 2009)

Pp2A-29B^EP2332

(White-Grindley et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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