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General Information
Symbol
Dmel\InRdel.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0156354
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-InR.del
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of InR in which most of the alpha subunit has been deleted. This mimics a constitutively active human InR described by Ellis et al., 1987 (PMID:2842659).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of InRdel.UAS under the control of Scer\GAL4Tub.PU in MARCM clones leads to a significant decrease in midgut cell number when compared to control adults.

Ectopic expression of InRdel.Scer\UAS in the larval body, under the control of Scer\GAL4c564, results in a 2.4-fold increase in cell size, compared to controls.

Expression of InRdel.Scer\UAS under the control of Scer\GAL4Bx-MS1096 results in a down-curled wing phenotype in 95.5% of flies.

Expression of InRdel.Scer\UAS under the control of Scer\GAL4GMR.PF results in an eye overgrowth phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The eye overgrowth phenotype caused by expression of InRdel.Scer\UAS under the control of Scer\GAL4GMR.PF is suppressed by Lnk4Q3/Lnk6S2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
InRdel.Scer\UAS
InRdel.UAS
Name Synonyms
Secondary FlyBase IDs
    References (7)