FlyBase Allele Report: Dmel\Lnk[4Q3]

General Information

Symbol

Dmel\Lnk^4Q3

Species

D. melanogaster

Name

FlyBase ID

FBal0243731

Feature type

allele

Associated gene

Dmel\Lnk

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Werz et al., 2009)

Mutagen

ethyl methanesulfonate

(Werz et al., 2009)

Progenitor genotype

Cytology

Description

Amino acid replacement: R449term.

(Werz et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:25,891,561..25,891,561 [+]

Nucleotide change:

C25891561T

Amino acid change:

Reported amino acid change:

R449term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Werz et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | adult stage (with Lnk^6S2)

(Werz et al., 2009)

decreased body size | pupal stage (with Lnk^6S2)

(Werz et al., 2009)

decreased cell number | somatic clone

(Werz et al., 2009)

female sterile (with Lnk^6S2)

(Werz et al., 2009)

visible | somatic clone

(Werz et al., 2009)

Phenotype Manifest In

eye (with Lnk^6S2)

(Werz et al., 2009)

eye photoreceptor cell | somatic clone

(Werz et al., 2009)

head | somatic clone

(Werz et al., 2009)

ommatidium (with Lnk^6S2)

(Werz et al., 2009)

oocyte (with Lnk^6S2)

(Werz et al., 2009)

ovary (with Lnk^6S2)

(Werz et al., 2009)

rhabdomere | somatic clone

(Werz et al., 2009)

wing disc | somatic clone

(Werz et al., 2009)

Detailed Description

Statement

Reference

Flies containing homozygous clones induced using the eyFLP technique have smaller heads than normal ("pinhead" phenotype).

Lnk^4Q3/Lnk^6S2 adults and pupae are smaller than controls. Both male and female Lnk^4Q3/Lnk^6S2 adults are severely reduced in dry weight compared to controls.

Lnk^4Q3/Lnk^6S2 adults have smaller eyes than normal due to a reduction in the number of ommatidia compared to wild-type.

Lnk^4Q3/Lnk^6S2 females are sterile, having small ovaries that only contain oocytes that have developed until the last previtellogenic stage.

Lnk^4Q3/Lnk^6S2 flies have elevated levels of lipids compared to control flies.

Photoreceptor cells and rhabdomeres within homozygous clones in the eye are smaller than normal.

Mutant clones in the wing disc are smaller than their wild-type sister clones and contain fewer cells.

(Werz et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Lnk^6S2/Lnk^4Q3 is a suppressor of visible phenotype of InR^del.UAS, Scer\GAL4^GMR.PF

(Werz et al., 2009)

NOT Suppressor of

Statement

Reference

Lnk^6S2/Lnk^4Q3 is a non-suppressor of visible phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^GMR.PF

(Werz et al., 2009)

Other

Statement

Reference

Df(2L)Exel6026/+, Lnk^6S2/Lnk^4Q3, chico¹ has viable phenotype

(Werz et al., 2009)

Lnk^6S2/Lnk^4Q3, chico^flp147E/chico¹ has lethal phenotype

(Werz et al., 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

Lnk^6S2/Lnk^4Q3 is a suppressor of eye phenotype of InR^del.UAS, Scer\GAL4^GMR.PF

(Werz et al., 2009)

NOT Suppressor of

Statement

Reference

Lnk^6S2/Lnk^4Q3 is a non-suppressor of eye phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^GMR.PF

(Werz et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The eye overgrowth phenotype caused by expression of InR^del.Scer\UAS under the control of Scer\GAL4^GMR.PF is suppressed by Lnk^4Q3/Lnk^6S2.

The eye overgrowth phenotype caused by expression of Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} under the control of Scer\GAL4^GMR.PF is not suppressed by Lnk^4Q3/Lnk^6S2.

(Werz et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Lnk^6S2/Lnk^4Q3 is rescued by Lnk^+t6

(Werz et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Lnk^4Q3

(Almudi et al., 2013)

lnk^4Q3

(Werz et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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