FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\E(spl)m8-HLHUAS.cKa
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General Information
Symbol
Dmel\E(spl)m8-HLHUAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0156612
Feature type
allele
Associated gene
Dmel\E(spl)m8-HLH
Associated Insertion(s)
Carried in Construct
P{UAS-m8.K}
Also Known As
UAS-m8
Key Links
Transgenic product class
wild_type
(Karandikar et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Karandikar et al., 2004)
Mutagen
in vitro construct
(Karandikar et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-m8.K}
Cytology
Description

UAS sequences drive expression of E(spl)m8-HLH.

(Karandikar et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
E(spl)m8-HLH
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of E(spl)Scer\UAS.cKa under the control of Scer\GAL4455.2 results in the almost complete loss of the four scutellar microchaeta.

      (Kahali et al., 2010)

      When E(spl)Scer\UAS.cKa is driven by Scer\GAL4455.2, the number of macrochaetae seen on the scutellum is reduced from 4 to an average of about 1. When E(spl)Scer\UAS.cKa is driven by Scer\GAL4sca-537.4 a potent bristle suppression is seen. When E(spl)Scer\UAS.cKa is driven by Scer\GAL4sca-109-68, no reduced eye phenotype is seen.

      (Karandikar et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      E(spl)m8-HLHUAS.cKa is rescued by Scer\GAL4455.2/E(spl)m8-HLH123-179.CtD.UAS

      (Kahali et al., 2010)
      Not rescued by

      E(spl)m8-HLHUAS.cKa is not rescued by Scer\GAL4455.2/E(spl)m8-HLHS159D.123-179.CtD.UAS

      (Kahali et al., 2010)
      Comments

      Co-expression of E(spl)123-179.CtD.Scer\UAS restores 2-3 of the scutellar macrochaeta lost in a Scer\GAL4455.2>E(spl)Scer\UAS.cKa background. Often, socket cells and misshapen macrochaeta are found.

      Co-expression of E(spl)S159D.123-179.CtD.Scer\UAS does not restore the scutellar macrochaeta lost in a Scer\GAL4455.2>E(spl)Scer\UAS.cKa background.

      (Kahali et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      E(spl)Scer\UAS.cKa
      E(spl)m8-HLHScer\UAS.cKa
      E(spl)m8-HLHUAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)