FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CG35111
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General Information
Symbol
Dmel\CG35111
Species
D. melanogaster
Name
FlyBase ID
FBal0156993
Feature type
allele
Associated gene
Dmel\CG3511
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Edgar et al., 2005, Parks, 2004.5.6)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C569T. Nucleotide substitution: A570G. In addition to the two missense mutations, there is a single base pair deletion at nucleotide 572. These changes are predicted to cause a frameshift at amino acid 133 and the early truncation of the protein at residue 158.

(Edgar et al., 2005)

Nucleotide substitution: C578T. Nucleotide substitution: A579G. 1 bp deletion of C581. Amino acid replacement: N133E. Frameshift causes 24 novel amino acids before a stop codon.

(Parks, 2004.5.6)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:24,572,411..24,572,411 [+]
Reported amino acid change:

N133E|CG3511-PA

Comment:

Deletion of a single C residue leads to a frameshift and truncation of the CDS after 24 novel amino acids. Two missense mutations are also observed in CG35111.

(Edgar et al., 2005, Parks, 2004.5.6)
point_mutation
2R:24,572,408..24,572,408 [+]
Nucleotide change:

C24572408T

Reported nucleotide change:

C569T

Amino acid change:

T132T | CG3511-PA; T132T | CG3511-PB

Reported amino acid change:

T133T

Comment:

One of two missense mutations observed in CG35111. In addition, a single base is deleted leading to a frameshift.

(Edgar et al., 2005, Parks, 2004.5.6)
point_mutation
2R:24,572,409..24,572,409 [+]
Nucleotide change:

A24572409G

Reported nucleotide change:

A570G

Amino acid change:

N133D | CG3511-PA; N133D | CG3511-PB

Reported amino acid change:

N133E

Comment:

One of two missense mutations observed in CG35111. In addition, a single base is deleted in same codon leading to a frameshift.

(Edgar et al., 2005, Parks, 2004.5.6)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the eye induced in an Rbf+ background are viable. Homozygous larvae have an enlarged body phenotype compared to their heterozygous siblings. These "large larvae" wander for an extended period before death, although rare escapers can progress to giant pupae that fail to eclose as adults.

      (Edgar et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      CG35111, RbfSLS-15 has cell lethal | somatic clone phenotype

      (Edgar et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygous CG35111 clones induced in the eye in a RbfSLS-15 background do not survive.

      (Edgar et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      CG35112

      (Edgar et al., 2005)

      CG35112

      (Parks, 2004.5.6)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Selected as: a mutation that results in synthetic cell lethality in clones in the eye in a RbfSLS-15 background.

      (Edgar et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG35111
      KE1-1
      (Edgar et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)