FlyBase Allele Report: Dmel\Rcc1[UU92]

General Information

Symbol

Dmel\Rcc1^UU92

Species

D. melanogaster

Name

FlyBase ID

FBal0157264

Feature type

allele

Associated gene

Dmel\Rcc1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Shi and Skeath, 2004)

Mutagen

ethyl methanesulfonate

(Shi and Skeath, 2004)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G1114A. Amino acid replacement: G?R. The mutation is in the middle of the fourth RCC1 repeat.

(Shi and Skeath, 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:5,931,660..5,931,660 [-]

Nucleotide change:

G5931660A

Reported nucleotide change:

G1114A

Amino acid change:

G208R | Rcc1-PA; G208R | Rcc1-PB; G208R | Rcc1-PC

Reported amino acid change:

G?R

(Shi and Skeath, 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

central nervous system | lateral

(Shi and Skeath, 2004)

central nervous system | lateral (with Df(3L)ZN47)

(Shi and Skeath, 2004)

larval EL neuron

(Shi and Skeath, 2004)

larval EL neuron (with Df(3L)ZN47)

(Shi and Skeath, 2004)

Detailed Description

Statement

Reference

Homozygous mutant embryos exhibit an approximately 50% reduction of EL neurons with 3-5 ELs developing per abdominal hemisegment. These mutant embryos also exhibit morphological defects in the lateral CNS as the lateral margin of mutant nerve cords appear rough and scalloped relative to wild-type.

(Shi and Skeath, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Rcc1^EP3630

(Shi and Skeath, 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Bj1^UU92

Rcc1^UU92

dRCC1^UU92

(Shi and Skeath, 2004)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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