FlyBase Allele Report: Dmel\Acf[2]

General Information

Symbol

Dmel\Acf²

Species

D. melanogaster

Name

FlyBase ID

FBal0157503

Feature type

allele

Associated gene

Dmel\Acf

Associated Insertion(s)

Carried in Construct

Also Known As

Acf1²

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Fyodorov et al., 2004)

Progenitor genotype

P{EPgy2}Acf^EY08629

(Fyodorov et al., 2004)

Cytology

Description

Imprecise excision of the P{EPgy2}Acf1^EY08629 transposon deletes the first Acf1 intron and portions of the first and second introns.

(Fyodorov et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:31,794,042..31,794,912 [+]

Comment:

Estimated endpoints of an 871 bp deletion resulting from the imprecise excision of P{EPgy2}Acf^EY08629. The deletion removes sequences from the 5' UTR and into the coding region of Acf.

(Fyodorov et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile | recessive

(Fyodorov et al., 2004)

partially lethal - majority die | recessive

(Fyodorov et al., 2004)

viable | recessive

(Fyodorov et al., 2004)

Phenotype Manifest In

egg chamber

(Börner et al., 2016)

nucleus | blastoderm stage

(Chioda et al., 2010)

Detailed Description

Statement

Reference

A subset of Acf²/Acf² mutant egg chambers display cell packaging defects.

(Börner et al., 2016)

The proper polar organisation of chromatin is still observed in many blastoderm nuclei of homozygous Acf1² mutants, however, the mutants show a higher degree of variability of nuclear organisation than wild-type.

(Chioda et al., 2010)

About 60% of the expected progeny survive. Those that do are fertile and phenotypically normal.

(Fyodorov et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

Acf², Df(3L)Pc has abdominal tergite 3 phenotype

(Fyodorov et al., 2004)

Acf², Df(3L)Pc has abdominal tergite 4 phenotype

(Fyodorov et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The combination of Df(3L)Pc heterozygotes and Acf1² leads to a stronger extra sex combs phenotype than seen in Df(3L)Pc alone. 61% (compared to 18% in controls) of males have extra sex combs on the second and/or third pairs of legs. The combination of Df(3L)Pc heterozygotes and Acf1² leads to a stronger extra sex combs phenotype than seen in Df(3L)Pc alone. 58% (compared to 18% in controls) of males have extra sex combs on the second and/or third pairs of legs. In addition over half of males exhibit ectopic pigmentation of their A3 and A4 abdominal tergites.

(Fyodorov et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Acf1²

(Börner et al., 2016, Mathew et al., 2014)

Acf1[2]

(Chioda et al., 2010)

Acf²

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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