FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\vnΔIg.UAS
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General Information
Symbol
Dmel\vnΔIg.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0158525
Feature type
allele
Associated gene
Dmel\vn
Associated Insertion(s)
Carried in Construct
P{UAS-vn.ΔIg}
Key Links
Transgenic product class
inframe_deletion
(Donaldson et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Donaldson et al., 2004)
Mutagen
in vitro construct
(Donaldson et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-vn.ΔIg}
Cytology
Description

UAS regulatory sequences drive expression of vn lacking the Ig domain.

(Donaldson et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
vn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing vnΔIg.Scer\UAS under the control of Scer\GAL4vn.GAL4 have notched wing margins.

      (Austin et al., 2014)

      Expression of vnΔIg.Scer\UAS under the control of Scer\GAL4bs-1348 results in an extra vein phenotype in the wing. Adult escapers expressing vnΔIg.Scer\UAS (from a weaker P{UAS-vn.ΔIg} insertion line) under the control of Scer\GAL469B have a moderate extra vein phenotype in the wing and the wing margins are serrated. This wing phenotype is rescued by co-expression of vnΔEGF.Scer\UAS. Expression of vnΔIg.Scer\UAS under the control of Scer\GAL4T80 results in bloated larvae. The brains and imaginal discs in these larvae are smaller than normal and show reduced levels of BrdU incorporation.

      (Donaldson et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL469B, vnΔIg.UAS has visible phenotype, suppressible by aosUAS.cHa/Scer\GAL469B

      (Donaldson et al., 2004)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL469B, vnΔIg.UAS has wing vein | ectopic phenotype, suppressible by aosUAS.cHa/Scer\GAL469B

      (Donaldson et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of argosScer\UAS.cHa rescues the extra wing vein phenotype caused be expression of vnΔIg.Scer\UAS under the control of Scer\GAL469B.

      (Donaldson et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      vnΔIg.UAS/Scer\GAL4vn-GAL4 rescues vnL6/vnGAL4

      (Austin et al., 2014)
      Comments

      Expression of vnΔIg.Scer\UAS under the control of Scer\GAL4vn.GAL4 rescues the lethality seen in vnL6/vnGAL4 mutant flies. The wings of these flies are abnormal and have deletion of wing margin bristles and notched margins, a phenotype that is also seen when this transgene is expressed in a wild type fly.

      (Austin et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      vnΔIg.Scer\UAS
      vnΔIg.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)