FlyBase Allele Report: Dmel\topi[Z3-3767]

General Information

Symbol

Dmel\topi^Z3-3767

Species

D. melanogaster

Name

FlyBase ID

FBal0158554

Feature type

allele

Associated gene

Dmel\topi

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Perezgasga et al., 2004)

Mutagen

ethyl methanesulfonate

(Perezgasga et al., 2004)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G1550A. Amino acid replacement: G516D.

(Perezgasga et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:9,776,952..9,776,952 [+]

Nucleotide change:

G9776952A

Reported nucleotide change:

G1550A

Amino acid change:

G517D | topi-PA

Reported amino acid change:

G516D

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

(Perezgasga et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | male

(Perezgasga et al., 2004)

female fertile

(Perezgasga et al., 2004)

male sterile

(Perezgasga et al., 2004)

viable

(Perezgasga et al., 2004)

Phenotype Manifest In

primary spermatocyte & nuclear chromosome

(Perezgasga et al., 2004)

primary spermatocyte & nuclear chromosome (with Df(3R)by10)

(Perezgasga et al., 2004)

secondary spermatocyte

(Perezgasga et al., 2004)

spermatid

(Perezgasga et al., 2004)

Detailed Description

Statement

Reference

The testes of topi^Z3-3767/topi^Z3-3767 adult males contain germ cell cysts up to and including mature primary spermatocytes, but few spermatocytes undergo meiotic division. The mature spermatocytes present in topi^Z3-3767/Df(3R)by10 or topi^Z3-3767 homozygous mutant testes resemble wild-type mature primary spermatocytes but have a more compact chromosomal morphology than wild-type primary spermatocytes in late G2, immediately prior to the onset of meiosis.

(Perezgasga et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Zuker

(Perezgasga et al., 2004)

From C.Zucker's collection of viable, male sterile lines.

(Perezgasga et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

topi^Z3-3767

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close