FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\timeoutc06976
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General Information
Symbol
Dmel\timeoutc06976
Species
D. melanogaster
Name
FlyBase ID
FBal0158565
Feature type
allele
Associated gene
Dmel\timeout
Associated Insertion(s)
PBac{PB}timeoutc06976
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Benna et al., 2010)
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{PB}timeoutc06976
Cytology
Description
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous males that have previously courted non-receptive females show a significant reduction in courtship index compared to control males that have not undergone conditioning (as occurs in wild-type males).

      (Baggio et al., 2013)

      Brains from larvae either homozygous or hemizygous (over Df(3R)Exel6167) for timeoutc06976 consistently exhibited a substantial increase in the number of metaphases with chromosome aberrations compared to controls.

      Chromosome breakage is significantly increased compared to wild-type in larval brains under hydroxyurea (HU)-induced deoxyribonucleotide triphosphate (dNTP) pool depletion in homozygous timeoutc06976 mutants.

      Circadian light entrainment is different from controls in timeoutc06976 heterozygotes compared to controls. Heterozygous timeoutc06976 flies are significantly more reactive than their corresponding controls in the advance zone at Zeitgeber time 19 and 21.

      (Benna et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      timeoutc06976 has chromosome | larval stage phenotype, enhanceable by mei-4129D

      (Benna et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Larval brains from mei-4129D; timeoutc06976 double mutants show a dramatic increase in the frequency of aberrant metaphases with respect to either single mutant. The prevalent defect of in mei-4129D; timeoutc06976 mutant brains consists of metaphases with extensive chromosome fragmentation, a phenotype rarely observed in either mei-4129D or timeoutc06976 single mutants.

      (Benna et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tim2c06976
      (Baggio et al., 2013)
      timeoutc06976
      Name Synonyms
      Secondary FlyBase IDs
        References (4)