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General Information
Symbol
Dmel\sniUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Botella
FlyBase ID
FBal0158625
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-sni
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of sni.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI under normal oxygen conditions does not extend the lifespan of adult flies. Expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI under hyperoxia (99.5% oxygen) results in a significant extension of the mean and maximum lifespan (43% and 44.4% respectively) compared to control flies. In addition, the flies expressing are substantially protected from the brain degeneration that is normally induced by hyperoxia. Expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI counteracts the effect of age on walking speed, improving the performance of 20- and 30- day old flies in a negative geotaxis assay by 63% and 78.8% respectively.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Overexpression of sniScer\UAS.cBa partially suppresses the decreased survival phenotype of flies expressing Hsap\APPArctic.Scer\UAS.T:nec under the control of Scer\GAL4elav-C155.

Overexpression of sniScer\UAS.cBa does not significantly suppress the decline in locomotor function of flies expressing Hsap\APPScer\UAS.T:nec under the control of Scer\GAL4elav-C155.

Complementation and Rescue Data
Comments

The neuronal and glial cell death that is seen in the lamina of sni1 adults as they age is rescued by expression of sniScer\UAS.cBa under the control of Scer\GAL4elav-C155. The reduced lifespan of sni1 flies seen under normal oxygen conditions and under hyperoxia (99.5% oxygen) is rescued by expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI. The impaired performance of sni1 flies in negative geotaxis experiments is improved by expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
sniScer\UAS.cBa
sniUAS.cBa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Botella
Secondary FlyBase IDs
    References (2)