FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sniUAS.cBa
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General Information
Symbol
Dmel\sniUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Botella
FlyBase ID
FBal0158625
Feature type
allele
Associated gene
Dmel\sni
Associated Insertion(s)
Carried in Construct
P{UAS-sni.B}
Also Known As
UAS-sni
Key Links
Transgenic product class
wild_type
(Botella et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Botella et al., 2004)
Mutagen
in vitro construct
(Botella et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-sni.B}
Cytology
Description

UAS regulatory sequences drive expression of sni.

(Botella et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sni
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI under normal oxygen conditions does not extend the lifespan of adult flies. Expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI under hyperoxia (99.5% oxygen) results in a significant extension of the mean and maximum lifespan (43% and 44.4% respectively) compared to control flies. In addition, the flies expressing are substantially protected from the brain degeneration that is normally induced by hyperoxia. Expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI counteracts the effect of age on walking speed, improving the performance of 20- and 30- day old flies in a negative geotaxis assay by 63% and 78.8% respectively.

      (Botella et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Overexpression of sniScer\UAS.cBa partially suppresses the decreased survival phenotype of flies expressing Hsap\APPArctic.Scer\UAS.T:nec under the control of Scer\GAL4elav-C155.

      Overexpression of sniScer\UAS.cBa does not significantly suppress the decline in locomotor function of flies expressing Hsap\APPScer\UAS.T:nec under the control of Scer\GAL4elav-C155.

      (Rival et al., 2009)
      Complementation and Rescue Data
      Rescues

      sniUAS.cBa/Scer\GAL4GMR23E10 rescues sni1

      (Rorsman et al., 2025)

      sniUAS.cBa/Scer\GAL4nSyb.PS rescues sni1

      (Rorsman et al., 2025)

      sniUAS.cBa/Scer\GAL4Act5C.PI rescues sni1

      (Botella et al., 2004)

      sniUAS.cBa/Scer\GAL4elav-C155 rescues sni1

      (Botella et al., 2004)
      Comments

      The neuronal and glial cell death that is seen in the lamina of sni1 adults as they age is rescued by expression of sniScer\UAS.cBa under the control of Scer\GAL4elav-C155. The reduced lifespan of sni1 flies seen under normal oxygen conditions and under hyperoxia (99.5% oxygen) is rescued by expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI. The impaired performance of sni1 flies in negative geotaxis experiments is improved by expression of sniScer\UAS.cBa under the control of Scer\GAL4Act5C.PI.

      (Botella et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      sniScer\UAS.cBa
      sniUAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Botella
      (Botella et al., 2004)
      Secondary FlyBase IDs
        References (3)