FB2026_02 , released June 18, 2026
Allele: Dmel\ppk11f02053
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General Information
Symbol
Dmel\ppk11f02053
Species
D. melanogaster
Name
FlyBase ID
FBal0158781
Feature type
allele
Associated gene
Dmel\ppk11
Associated Insertion(s)
PBac{WH}ppk11f02053
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{WH}ppk11f02053
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous and ppk11f02053/Df(2L)BSC240 third instar larvae show no significant increase in quantal content at the neuromuscular junction in the presence of the glutamate receptor antagonist philanthotoxin-433 (10μM), indicating a defect in synaptic homeostasis. In the absence of philanthotoxin-433, mutant third instar larvae show no significant change in evoked excitatory postsynaptic potential (EPSP) amplitude or quantal content at the neuromuscular junction compared to wild-type controls, while there is a minor reduction in miniature mEPSP amplitude.

      The morphology of the neuromuscular junction is normal in mutant third instar larvae.

      (Younger et al., 2013)

      Homozygous males show normal levels of courtship: the courtship index and the fraction of males initiating courtship in the presence of decapitated females is not significantly different from that of wild-type males.

      (Liu et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ppk11f02053/ppk16MB11536 transheterozygous third instar larvae show no significant increase in quantal content at the neuromuscular junction in the presence of the glutamate receptor antagonist philanthotoxin-433 (10μM), indicating a defect in synaptic homeostasis. In the absence of philanthotoxin-433, basal synaptic transmission is normal in these animals.

      (Younger et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      f02053
      (Liu et al., 2012)
      ppk11PBac
      (Younger et al., 2013)
      ppk11f02053
      Name Synonyms
      Secondary FlyBase IDs
        References (3)