FlyBase Allele Report: Dmel\Tsc1[1A2]

General Information

Symbol

Dmel\Tsc1^1A2

Species

D. melanogaster

Name

FlyBase ID

FBal0159593

Feature type

allele

Associated gene

Dmel\Tsc1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | somatic clone

(Luo et al., 2020)

lethal - all die before end of larval stage (with Tsc1^2X1)

(Stocker et al., 2003)

some die during larval stage (with Tsc1^2X1)

(Stocker et al., 2003)

Phenotype Manifest In

dendrite | adult stage | somatic clone

(Luo et al., 2020)

distal medullary amacrine neuron Dm8a | adult stage | somatic clone

(Luo et al., 2020)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Tsc1^1A2 has abnormal neuroanatomy | adult stage | somatic clone phenotype, non-enhanceable by sev⁴/sev⁴

(Luo et al., 2020)

Suppressed by

Statement

Reference

Tsc1^2X1/Tsc1^1A2 has lethal | larval stage phenotype, suppressible by Rheb^2D1/Rheb^7A1

(Stocker et al., 2003)

NOT suppressed by

Statement

Reference

Tsc1^1A2 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by sev⁴/sev⁴

(Luo et al., 2020)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Tsc1^1A2 has distal medullary amacrine neuron Dm8a | adult stage | somatic clone phenotype, non-enhanceable by sev⁴/sev⁴

(Luo et al., 2020)

Tsc1^1A2 has dendrite | adult stage | somatic clone phenotype, non-enhanceable by sev⁴/sev⁴

(Luo et al., 2020)

NOT suppressed by

Statement

Reference

Tsc1^1A2 has distal medullary amacrine neuron Dm8a | somatic clone | adult stage phenotype, non-suppressible by sev⁴/sev⁴

(Luo et al., 2020)

Tsc1^1A2 has dendrite | somatic clone | adult stage phenotype, non-suppressible by sev⁴/sev⁴

(Luo et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Rheb^2D1/Rheb^7A1 suppresses the pupal lethality due to Tsc1^2X1/Tsc1^1A2. The resulting animals are smaller than doubly heterozygous controls (Tsc1^2X1 Rheb^2D1/+) at both pupal and adult stages.

(Stocker et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Tsc1^1A2

(Luo et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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