FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rheb4L1
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General Information
Symbol
Dmel\Rheb4L1
Species
D. melanogaster
Name
FlyBase ID
FBal0159906
Feature type
allele
Associated gene
Dmel\Rheb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Stocker et al., 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: K101term.

(Stocker et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:5,569,754..5,569,754 [+]
Nucleotide change:

A5569754T

Amino acid change:

K101term | Rheb-PA; K101term | Rheb-PB

Reported amino acid change:

K101term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Stocker et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Rheb4L1 is a suppressor of increased cell death | somatic clone phenotype of AxnS044230, Rbf15aΔ

      (Zhang et al., 2014)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Rheb4L1 is a suppressor of eye disc | somatic clone phenotype of AxnS044230, Rbf15aΔ

      (Zhang et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rheb4L1 significantly decreases the increase in apoptosis anterior to the morphogenetic furrow seen in AxnS044230 Rbf15aΔ mutant eye disc clones.

      Rbf15aΔ enhances the reduction in ATP/ADP ratio seen in eye discs with AxnS044230 mutant clones (induced in a minute background). This enhancement is suppressed to the levels seen in AxnS044230 single mutants by Rheb4L1.

      (Zhang et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rheb4L1
      (Zhang et al., 2014)
      rheb4L1
      (Zhang et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)