FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nrx-1d08766
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General Information
Symbol
Dmel\Nrx-1d08766
Species
D. melanogaster
Name
FlyBase ID
FBal0160123
Feature type
allele
Associated gene
Dmel\Nrx-1
Associated Insertion(s)
P{XP}Nrx-1d08766
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
P{XP}Nrx-1d08766
Cytology
Description

P{XP}Nrx-1d08766 is located approximately 200bp upstream of Nrx-1.

(Li et al., 2007)

P{XP}Nrx-1d08766 is inserted 198b upstream of the translation initation codon of the Nrx-1.

(Zeng et al., 2007)
Allele components
Component
Use(s)
Inserted element
P{XP}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nrx-1d08766 heterozygous third instar larvae do not display any neuromuscular junction (NMJ) morphological defects (the total bouton area, number of boutons as well as number of branch points per NMJ is comparable to wild-type) but the active zone density at the NMJ is significantly increased relative to controls. Larval locomotor speed is not affected compared controls and the average cell body size of cells in the ventral nerve cord is also not significantly different.

      (Pandey et al., 2017)

      Associative learning is reduced in Nrx-1d08766 mutants (testing for their ability to associate odors with a fructose reward in an individual-animal assay).

      (Zeng et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Nrx-1[+]/Nrx-1d08766 is a suppressor of NMJ bouton phenotype of Hsap\DISC1UAS.Tag:HA, Scer\GAL4αTub84B.PL

      (Pandey et al., 2017)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The reduced total neuromuscular junction (NMJ) bouton area in third instar larvae expressing Hsap\DISC1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4αTub84B.PL is rescued by combination with a single copy of Nrx-1d08766 but this also results in significant decrease in the number of branch points per NMJ, which is not observed in either of the single mutants alone. Number of boutons per NMJ remains comparable to wild-type.

      Similarly, Scer\GAL4αTub84B.PL>Hsap\DISC1Scer\UAS.T:Ivir\HA1;Nrx-1d08766/+ larvae show significant decrease in both average and peak locomotor speed, a phenotype not seen in either of the single mutants. Cell body size of neurons in the ventral nerve cord is not affected and comparable to wild-type.

      (Pandey et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Nrx-1d08766
      dnrx1d08766
      (Pandey et al., 2017)
      dnrxd08766
      (Sun et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)