FlyBase Allele Report: Dmel\Gαq[f04219]

General Information

Symbol

Dmel\Gαq^f04219

Species

D. melanogaster

Name

FlyBase ID

FBal0160452

Feature type

allele

Associated gene

Dmel\Gαq

Associated Insertion(s)

PBac{WH}Gαq^f04219

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{WH}Gαq^f04219

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{WH}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:12,613,157..12,613,163 [+]

(Banerjee et al., 2006, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of first instar larval stage

(Banerjee et al., 2006)

some die during first instar larval stage

(Banerjee et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

Gαq^f04219/+ mutant larvae show a small decrease in spontaneous miniature neurotransmission. A compensatory increase in quantal content means that evoked neurotransmission is unaffected.

(Brusich et al., 2015)

Gα49B^f04219 homozygotes die at around 10-12 hours post-hatching.

(Banerjee et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Gαq^f04219/Galphaq[+], GluRIIA^SP16 has abnormal neurophysiology phenotype

(Brusich et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Gαq^f04219 partially prevents the compensatory increase in quantal content seen in the NMJs of GluRIIA^SP16 mutant larvae with reduced quantal size, resulting in impaired evoked neurotransmission. These is some increase in quantal content compared with Gαq^f04219/+ controls, but not enough to compensate for the reduced quantal size.

(Brusich et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

18745