FlyBase Allele Report: Dmel\Fmr1[unspecified]

General Information

Symbol

Dmel\Fmr1^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0160460

Feature type

allele

Associated gene

Dmel\Fmr1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of fragile X syndrome

CEA

(Zhang et al., 2017, Cvetkovska et al., 2013, Kelley et al., 2007)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of fragile X syndrome

is ameliorated by Dscam1^unspecified

(Cvetkovska et al., 2013)

model of Down syndrome

is ameliorated by Dscam1^unspecified

(Cvetkovska et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior

(Banerjee et al., 2007)

abnormal locomotor rhythm

(Banerjee et al., 2007)

abnormal neuroanatomy

(Myrick et al., 2015, Cvetkovska et al., 2013)

abnormal neuroanatomy | dominant

(Schenck et al., 2004)

abnormal neuroanatomy | larval stage

(Banerjee et al., 2007)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^RapGAP1-OK6

(Zhang et al., 2017)

Phenotype Manifest In

axon | ectopic

(Cvetkovska et al., 2013)

embryonic/larval neuromuscular junction

(Myrick et al., 2015)

mechanosensory neuron

(Cvetkovska et al., 2013)

neuromuscular junction & synapse

(Schenck et al., 2004)

neuromuscular junction | third instar larval stage

(Zhang et al., 2017)

neuron & beta-lobe

(Banerjee et al., 2007)

terminal bouton

(Myrick et al., 2015)

terminal bouton | third instar larval stage

(Zhang et al., 2017)

type I bouton | increased number

(Banerjee et al., 2007)

Detailed Description

Statement

Reference

Fmr1^unspecified homozygotes present significant increases in the number of dendrite branches, in the number of total boutons and in the proportion of satellite boutons at the third instar larval muscle 4 neuromuscular junction, as compared to control.

(Zhang et al., 2017)

The NMJs of homozygous Fmr1^unspecified mutant flies exhibit an increase in length and branching compared to controls.

(Myrick et al., 2015)

'Fmr1[null]' flies show a significant increase in the total branch length of the pSc axonal arbour, resulting from a significant increase in the number of ectopic branches, compared to WT. Other targeting errors include branch misrouting, midline crossing, and missing branches.

(Cvetkovska et al., 2013)

Flies homozygous for a null allele of Fmr1 show an increase in the number of type I boutons at the larval neuromuscular junction compared to wild type (muscles 6/7, 12 and 4 from segment A3 have been studied).

Flies homozygous for a null allele of Fmr1 show a high frequency of midline crossing of mushroom body β-lobe neurons.

Most flies homozygous for a null allele of Fmr1 are arrhythmic for locomotor activity under constant darkness conditions.

Males homozygous for a null allele of Fmr1 show a reduced courtship index towards virgin females than that seen in wild-type males.

(Banerjee et al., 2007)

Heterozygous larvae have significantly longer synapses at the neuromuscular junction (119.8 +/- 5.1 μm) compared to wild-type larvae (111.1 μm).

(Schenck et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Fmr1^unspecified has abnormal neuroanatomy phenotype, suppressible by Dscam1^unspecified/Dscam1[+]

(Cvetkovska et al., 2013)

Fmr1^unspecified has abnormal neuroanatomy | dominant phenotype, suppressible by Hem[+]/Hem⁰³³³⁵

(Schenck et al., 2004)

Fmr1^unspecified has abnormal neuroanatomy | dominant phenotype, suppressible by SCAR^Δ37/SCAR[+]

(Schenck et al., 2004)

Fmr1^unspecified has abnormal neuroanatomy | dominant phenotype, suppressible by Sra-1[+]/Cyfip^85.1

(Schenck et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

Fmr1^unspecified has mechanosensory neuron phenotype, suppressible by Dscam1^unspecified/Dscam1[+]

(Cvetkovska et al., 2013)

Fmr1^unspecified has axon | ectopic phenotype, suppressible by Dscam1^unspecified/Dscam1[+]

(Cvetkovska et al., 2013)

Fmr1^unspecified has neuromuscular junction & synapse phenotype, suppressible by Hem[+]/Hem⁰³³³⁵

(Schenck et al., 2004)

Fmr1^unspecified has neuromuscular junction & synapse phenotype, suppressible by SCAR^Δ37/SCAR[+]

(Schenck et al., 2004)

Fmr1^unspecified has neuromuscular junction & synapse phenotype, suppressible by Sra-1[+]/Cyfip^85.1

(Schenck et al., 2004)

Suppressor of

Statement

Reference

Fmr1^unspecified/Fmr1[+] is a suppressor | partially of neuropil phenotype of futsch^olk1

(Bettencourt da Cruz et al., 2005)

Fmr1^unspecified/Fmr1[+] is a suppressor | partially of microtubule & antennal lobe phenotype of futsch^olk1

(Bettencourt da Cruz et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

'Dscam[null]'/+ reduces the frequency and type of pSc axonal arbor targeting errors in 'Fmr1[null]' homozygotes.

(Cvetkovska et al., 2013)

In futsch^olk1; Fmr1^unspecified/+ flies, the size of vacuoles in the mechanosensory neuropil of the ventrolateral protocerebrum is reduced by approximately one third compared to futsch^olk1 mutants of the same age. futsch^olk1; Fmr1^unspecified/+ mutants also show a suppression of the abnormal microtubule antennal lobe pattern seen in futsch^olk1 flies.

(Bettencourt da Cruz et al., 2005)

The overgrown synapse phenotype seen at the neuromuscular junction of Fmr1^unspecified/+ larvae is suppressed by one copy of Sra-1^85.1, Hem⁰³³³⁵ or SCAR^Δ37.

(Schenck et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Fmr1^unspecified is rescued by Fmr1^UAS.cMa/Scer\GAL4^da.G32

(Myrick et al., 2015)

Fmr1^unspecified is rescued by Scer\GAL4^elav-C155/Fmr1^UAS.cMa

(Myrick et al., 2015)

Not rescued by

Fmr1^unspecified is not rescued by Scer\GAL4^da.G32/Fmr1^R140Q.UAS

(Myrick et al., 2015)

Fmr1^unspecified is not rescued by Scer\GAL4^elav-C155/Fmr1^R140Q.UAS

(Myrick et al., 2015)

Comments

Ubiquitous expression of Fmr1^{R140Q.Scer\UAS} under the control of Scer\GAL4^da.G32 is unable to rescue the NMJ overgrowth and branching seen in Fmr1^unspecified mutant flies.

Pre-synaptic expression of Fmr1^{R140Q.Scer\UAS} under the control of Scer\GAL4^elav-C155 is unable to rescue the NMJ overgrowth and branching seen in Fmr1^unspecified mutant flies.

Ubiquitous expression of Fmr1^Scer\UAS.cMa under the control of Scer\GAL4^da.G32 rescues the NMJ overgrowth and branching seen in Fmr1^unspecified mutant flies.

Pre-synaptic expression of Fmr1^Scer\UAS.cMa under the control of Scer\GAL4^elav-C155 rescues the NMJ overgrowth and branching seen in Fmr1^unspecified mutant flies.

(Myrick et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Fmr1^null

(Cvetkovska et al., 2013)

Fmr1^unspecified

Name Synonyms

Secondary FlyBase IDs

References (9)

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