FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ced-12c06760
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General Information
Symbol
Dmel\Ced-12c06760
Species
D. melanogaster
Name
FlyBase ID
FBal0160703
Feature type
allele
Associated gene
Dmel\Ced-12
Associated Insertion(s)
PBac{PB}Ced-12c06760
Carried in Construct
Also Known As
elmoPB, elmoPB<up>c06760</up>
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Geisbrecht et al., 2008)
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{PB}Ced-12c06760
Cytology
Description

Maternal and zygotic Ced-12c06760 mutants express some wild type transcript as well as two larger products. Aberrant splicing of the primary transcript occurs between exons 1 and 2, and introduces a stop codon 8 amino acids downstream from the end of exon 1.

(Geisbrecht et al., 2008)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Detached muscle fibres are present in stage 16-17 embryos derived from Ced-12c06760 germ line clones.

      (Liu et al., 2013)

      In embryos maternally and zygotically mutant for Ced-12c06760, significant axonal patterning defects are observed, including: an increased number of outer fascicle gaps, aberrant midline crossing of longitudinal axons, and misrouting of outer longitudinal axons.

      (Biersmith et al., 2011)

      Homozygous embryos have minor defects in myoblast fusion: a small number of myoblasts remain unfused and muscles are occasionally missing.

      Ced-12c06760/Df(2L)HO55 embryos exhibit modest myoblast fusion defects: the overall muscle pattern is unperturbed, but some unfused myoblasts are present just under the muscle layer.

      Germline clone embryos maternally mutant for Ced-12c06760 and zygotically heterozygous for Df(2L)Prl (that removes Ced-12) exhibit a greater number of missing muscles and unfused myoblasts compared to zygotic Ced-12c06760 trans-heterozygotes. The earlier specification of developing muscle cells, founder cells and fusion-competent cells appears to occur normally in these embryos.

      (Geisbrecht et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ced-12c06760 is rescued by Scer\GAL4Act.PU/Ced-12UAS.cGa

      (Geisbrecht et al., 2008)
      Comments

      Expression of Ced-12Scer\UAS.cGa under the control of Scer\GAL4Act.PU reverts the lethality of Ced-12c06760.

      (Geisbrecht et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Lethality is reverted by excision of PBac{PB}Ced-12c06760.

      (Geisbrecht et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      Ced-12c06760
      ELMOPB<up>c06760</up>
      (Geisbrecht et al., 2008)
      c06760
      (Winkler et al., 2015)
      ced-12PB06760
      (Van Goethem et al., 2012)
      elmoPB
      (Biersmith et al., 2011, Geisbrecht et al., 2008)
      elmoPB<up>c06760</up>
      (Biersmith et al., 2011, Geisbrecht et al., 2008)
      elmoPB[c06760]
      (Liu et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)