FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ced-128C6
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General Information
Symbol
Dmel\Ced-128C6
Species
D. melanogaster
Name
FlyBase ID
FBal0266884
Feature type
allele
Associated gene
Dmel\Ced-12
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Geisbrecht et al., 2008)
Mutagen
ethyl methanesulfonate
(Geisbrecht et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: G666R.

(Geisbrecht et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:12,100,362..12,100,362 [+]
Nucleotide change:

G12100362A

Amino acid change:

G666R | Ced-12-PA

Reported amino acid change:

G666R

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Could alternatively be a G to C nucleotide change; unspecified.

(Geisbrecht et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos have minor defects in myoblast fusion: a small number of myoblasts remain unfused and muscles are occasionally missing.

      Ced-128C6/Df(2L)HO55 embryos exhibit modest myoblast fusion defects: the overall muscle pattern is unperturbed, but some unfused myoblasts are present just under the muscle layer.

      Germline clone embryos maternally mutant for Ced-128C6 and zygotically heterozygous for Df(2L)Prl (that removes Ced-12) exhibit a greater number of missing muscles and unfused myoblasts compared to zygotic Ced-128C6 trans-heterozygotes.

      (Geisbrecht et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Ced-128C6
      ELMO8C6
      (Geisbrecht et al., 2008)
      dced-12[8c6]
      (Van Goethem et al., 2012)
      elmo8C6
      (Geisbrecht et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)