FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ranshie00091
Open Close
General Information
Symbol
Dmel\ranshie00091
Species
D. melanogaster
Name
FlyBase ID
FBal0160760
Feature type
allele
Associated gene
Dmel\ranshi
Associated Insertion(s)
PBac{RB}ranshie00091
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Lewandowski et al., 2010)
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{RB}ranshie00091
Cytology
Description

Insertion within intron 1, approximately 146bp downstream of the translational initiation site.

(Lewandowski et al., 2010)
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous males are viable, fertile and indistinguishable from wild type.

      Homozygous females fail to lay eggs. All egg chambers of homozygous females contain 16 germline cells, but they lack karyosomes. The nuclei of all the germline cells contain endoreplicated DNA that is typically seen in nurse cells. Spectrosome/fusome development appears indistinguishable from wild type in homozygous females. Meiosis is not restricted to a single cells in mutant germaria, as assessed by the presence of synaptonemal complexes in two adjacent cells within germarial region 3. In mutant cysts containing a single cell with synaptonemal complex, centrosomes accumulate within the cell containing the synaptonemal complex (as occurs in wild type), however, they are not detected within the posterior of the cell but are randomly placed within the cytoplasm.

      (Lewandowski et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ranshie00091 is rescued by ranshi+t4.2

      (Lewandowski et al., 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      FlyBase curator comment: The "Df(3R)ranshi[1]" chromosome and the allele called "ranshi[1]" in FBrf0210119 (ranshie00091 in FlyBase) are two separate mutations. The ranshie00091 allele is caused by the PBac{RB}ranshie00091 insertion. The Df(3R)ranshi1 chromosome is a different mutation derived by recombination between the Scer\FRT sites in PBac{RB}ranshie00091 and P{XP}d11678.

      (Lewandowski et al., 2010)
      Comments
      Comments

      Precise excision of the progenitor insertion reverts the mutant phenotype.

      (Lewandowski et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG9793e00091
      ranshi1
      (Lewandowski et al., 2010)
      ranshie00091
      Name Synonyms
      Secondary FlyBase IDs
        References (3)