FlyBase Allele Report: Dmel\tyf[e00614]

General Information

Symbol

Dmel\tyf^e00614

Species

D. melanogaster

Name

FlyBase ID

FBal0161355

Feature type

allele

Associated gene

Dmel\tyf

Associated Insertion(s)

PBac{RB}tyf^e00614

Carried in Construct

Also Known As

tyf^e

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{RB}tyf^e00614

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{RB}

gene trap

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:4,119,045..4,119,045 [+]

(Lim and Allada, 2013, Lim et al., 2011, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor rhythm | recessive

(Lim et al., 2011)

fertile

(Bloomington Drosophila Stock Center, 2004.11.6)

viable

(Bloomington Drosophila Stock Center, 2004.11.6)

Phenotype Manifest In

Detailed Description

Statement

Reference

tyf^e00614 adults do not show changes in the number of sLNv neurons, as compared to controls.

(Xu et al., 2019)

Mutant flies show defects in locomotor activity rhythms; under 12 hour light/12 hour dark conditions, the morning anticipation of lights-on is reduced compared to controls, and the rhythm is less robust, resulting in weak (58% of flies are rhythmic) but long periods (27.6 +/- 0.4 hours) under constant darkness conditions.

(Lim et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

tyf^e00614 has abnormal locomotor rhythm phenotype, suppressible by per^UAS.cBa/Scer\GAL4^P2.4.Pdf

(Lim et al., 2011)

NOT suppressed by

Statement

Reference

tyf^e00614 has abnormal locomotor rhythm phenotype, non-suppressible by tim^UAS.cYa/Scer\GAL4^P2.4.Pdf

(Lim et al., 2011)

tyf^e00614 has abnormal locomotor rhythm phenotype, non-suppressible by Clk^UAS.cZa/Scer\GAL4^P2.4.Pdf

(Lim et al., 2011)

NOT Enhancer of

Statement

Reference

tyf^e00614 is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

tyf^e00614 is a non-enhancer of decreased cell number | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

NOT Suppressor of

Statement

Reference

tyf^e00614 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

tyf^e00614 is a non-suppressor of decreased cell number | adult stage phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

tyf^e00614 is a non-enhancer of adult s-LNv neuron phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

NOT Suppressor of

Statement

Reference

tyf^e00614 is a non-suppressor of adult s-LNv neuron phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

The weakened rhythmicity seen in tyf^e00614 flies under constant darkness conditions is suppressed by expression of per^Scer\UAS.cBa under the control of Scer\GAL4^P2.4.Pdf but is not suppressed by expression of either tim^Scer\UAS.cYa or Clk^Scer\UAS.cZa under the control of Scer\GAL4^P2.4.Pdf.

(Lim et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

tyf^e00614 is rescued by tyf^UAS.Tag:V5/Scer\GAL4^P2.4.Pdf

(Lim and Allada, 2013)

tyf^e00614 is rescued by tyf^UAS.Tag:V5/Scer\GAL4^P2.4.Pdf

(Lim et al., 2011)

Not rescued by

tyf^e00614 is not rescued by tyf^{ΔC5.UAS.Tag:V5}/Scer\GAL4^P2.4.Pdf

(Lim and Allada, 2013)

Comments

Expression of tyf^{Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^P2.4.Pdf rescues the locomotor rhythm defects seen in tyf^e00614 mutant flies.

Expression of tyf^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^P2.4.Pdf rescues the locomotor rhythm defects seen in tyf^e00614 mutant flies.

Expression of tyf^{ΔC5.Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^P2.4.Pdf fails to rescue the locomotor rhythm defects seen in tyf^e00614 mutant flies.

Expression of tyf^{ΔC5.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^P2.4.Pdf fails to rescue the locomotor rhythm defects seen in tyf^e00614 mutant flies.

(Lim and Allada, 2013)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17872

w¹¹¹⁸ PBac{RB}tyf^e00614

Notes on Origin

Discoverer

Comments

Precise excision of the insertion reverts the circadian rhythm defects.

(Lim et al., 2011)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG4857^e00614

tyf(e)

(Xu et al., 2019)

tyf^e00614

(Lim et al., 2011)

tyf^e

(Lim and Allada, 2013, Lim et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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