FlyBase Allele Report: Dmel\jvl[f00590]

General Information

Symbol

Dmel\jvl^f00590

Species

D. melanogaster

Name

FlyBase ID

FBal0161492

Feature type

allele

Associated gene

Dmel\jvl

Associated Insertion(s)

PBac{WH}jvl^f00590

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

piggyBac activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Dubin-Bar et al., 2011)

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{WH}jvl^f00590

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{WH}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:14,751,256..14,751,256 [-]

(Baskar et al., 2019, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with jvl¹)

(Dubin-Bar et al., 2011)

lethal - all die before end of P-stage (with Df(3R)Exel6275)

(Dubin-Bar et al., 2011)

some die during pharate adult stage (with Df(3R)Exel6275)

(Dubin-Bar et al., 2011)

Phenotype Manifest In

egg (with jvl¹)

(Dubin-Bar et al., 2011)

macrochaeta (with jvl¹)

(Baskar et al., 2019, Dubin-Bar et al., 2011)

Detailed Description

Statement

Reference

jvl¹/jvl^f00590 adults exhibit bristle defects with a swollen tip containing misoriented actin ridges compared to controls.

(Baskar et al., 2019)

jvl¹/jvl^f00590 trans-heterozygotes show defective bristle tip morphology.

jvl¹/jvl^f00590 trans-heterozygotes are sterile and lay ventralized eggs.

(Dubin-Bar et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

jvl^f00590/jvl¹ is rescued by Scer\GAL4^nanos.PG/jvl^RA.UASp.GFP

(Dubin-Bar et al., 2011)

Partially rescued by

jvl^f00590/jvl¹ is partially rescued by Scer\GAL4^sca.PU/jvl^{C.UAS.mCherry}

(Baskar et al., 2019)

jvl^f00590/jvl¹ is partially rescued by Scer\GAL4^sca.PU/jvl^SKNN.UAS.GFP

(Baskar et al., 2019)

jvl^f00590/jvl¹ is partially rescued by Scer\GAL4^sca.PU/jvl^UAS.GFP

(Baskar et al., 2019)

jvl^f00590/jvl¹ is partially rescued by Scer\GAL4^sca.PU/jvl^UAS.mCherry

(Baskar et al., 2019)

Not rescued by

jvl^f00590/jvl¹ is not rescued by jvl^N.UAS.GFP/Scer\GAL4^sca.PU

(Baskar et al., 2019)

Comments

Expression of jvl^{RA.Scer\UAS.P\T.T:Avic\GFP} using Scer\GAL4^nos.PG rescues the female sterility of jvl¹/jvl^f00590 flies.

(Dubin-Bar et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

18348

w¹¹¹⁸; PBac{WH}jvl^f00590/TM6B, Tb¹

Notes on Origin

Discoverer

Separable from: An embryonic lethal mutation elsewhere on the 3rd chromosome.

(Dubin-Bar et al., 2011)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG3563^f00590

CG43162^D590

(Dubin-Bar et al., 2011)

CG43162^f00590

jvl²

(Dubin-Bar et al., 2011)

jvl^f00590

(Baskar et al., 2019, Baskar et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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