FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cenf04787
Open Close
General Information
Symbol
Dmel\Cenf04787
Species
D. melanogaster
Name
FlyBase ID
FBal0161954
Feature type
allele
Associated gene
Dmel\Cen
Associated Insertion(s)
PBac{WH}Cenf04787
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Cenf04787
Cytology
Description

PBac{WH} insertion within the coding region of Cenat codon 290.

(Kao and Megraw, 2009)
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The rate at which Cenf04787/Df(2L)Fs(2)Ket-RX32 females lay eggs that fail to hatch is significantly higher than the rate from wild type females.

      Embryos from Cenf04787/Df(2L)Fs(2)Ket-RX32 mothers have mitotic spindles that are frequently linked together - the severity of this phenotype is variable but highly penetrant. Cleavage furrows form aberrantly, are consistently less robust and have decreased furrow depth: overall, 27.85% of mutant embryos display broken/weak furrows at prophase/metaphase compared to 0.91% of wild type embryos. Astral microtubules are comparable to those in wild type.

      (Kao and Megraw, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressor of
      Statement
      Reference

      Cen[+]/Cenf04787 is a suppressor | partially of increased mortality during development phenotype of Fmr13/Fmr1Δ113M

      (Ryder et al., 2020)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Cen[+]/Cenf04787 is a suppressor | partially of mitotic spindle | embryonic stage phenotype of Fmr13/Fmr1Δ113M

      (Ryder et al., 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Presence of a single copy of cnnHK21 enhances the rate of embryo hatch failure from Cenf04787/Df(2L)Fs(2)Ket-RX32 mothers.

      (Kao and Megraw, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(2L)Fs(2)Ket-RX32/Cenf04787 is rescued by CenUASp.cKa

      (Kao and Megraw, 2009)
      Comments

      Scer\GAL4nos.UTR.T:Hsim\VP16-mediated expression of CenScer\UAS.P\T.cKa fully rescues the hatching rate deficiency seen from Cenf04787/Df(2L)Fs(2)Ket-RX32 females.

      (Kao and Megraw, 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG1962f04787
      Cenf04787
      cenf04787
      (Mehta et al., 2022, Bergalet et al., 2020, Ryder et al., 2020, Kao and Megraw, 2009)
      centrocortinf04787
      (Zheng et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)