FlyBase Allele Report: Dmel\Mis12[f03756]

General Information

Symbol

Dmel\Mis12^f03756

Species

D. melanogaster

Name

FlyBase ID

FBal0162730

Feature type

allele

Associated gene

Dmel\Mis12

Associated Insertion(s)

PBac{WH}Mis12^f03756

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{WH}Mis12^f03756

Cytology

Description

Insertion in the first intron.

(Venkei et al., 2011)

Allele components

Component

Use(s)

Inserted element

PBac{WH}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:6,968,809..6,968,809 [-]

(Zhao et al., 2019, Venkei et al., 2011, Gene Disruption Project members and Exelixis, 2005, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | embryonic stage

(Venkei et al., 2011)

lethal (with Df(3L)BSC27)

(Venkei et al., 2011)

lethal - all die during embryonic stage (with Df(3L)BSC224)

(Venkei et al., 2011)

lethal - all die during embryonic stage | recessive

(Venkei et al., 2011)

some die during embryonic stage (with Df(3L)BSC224)

(Venkei et al., 2011)

some die during embryonic stage | recessive

(Venkei et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

Cellularised mutant embryos contain body areas with lower cells densities than normal, in which cells have a high number of micronuclei and/or presumptive polyploid nuclei. Analysis of mitoses 15 and 16 in mutant embryos indicates that 3 broad categories of mitotic defect are seen; many cells show a pronounced delay in anaphase onset, chromosome mis-segregation is seen and some cells show a metaphase-like arrest.

(Venkei et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mis12^f03756/Mis12[+] is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^30.UAS.EGFP

(Kankel et al., 2020)

Mis12^f03756/Mis12[+] is a suppressor of visible | adult stage phenotype of Hsap\TARDBP^{M337V.UAS.Tag:MYC}, Scer\GAL4^GMR.PU