FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AktEY10012
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General Information
Symbol
Dmel\AktEY10012
Species
D. melanogaster
Name
FlyBase ID
FBal0162822
Feature type
allele
Associated gene
Dmel\Akt
Associated Insertion(s)
P{EPgy2}AktEY10012
Carried in Construct
Also Known As
Akt1EY10012
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}AktEY10012
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Inamdar et al., 2014)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  alcohol use disorder
      modeled by aru8.128
      (Eddison et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Akt1EY10012 heterozygous mutants exhibit extreme sensitivity to 1-octen-3-ol. These flies survive for approximately 13 days when exposed to 0.5ppm 1-octen-3-ol, significantly lower than the 18 days-long survival span observed for exposed wild-type flies.

      (Inamdar et al., 2014)

      Neuronal expression of Pi3K92EA2860C.Scer\UAS under the control of Scer\GAL4elav-C155 decreases sensitivity to ethanol sedation.

      (Eddison et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies over-expressing Akt1EY10012 in neurons (with Scer\GAL4elav-C155) in an aru8.128 background show increased ethanol sensitivity, indicating suppression of the Akt1EY10012 phenotype.

      (Eddison et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Akt1EY10012
      AktEY10012
      (Kang et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)