FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Glidv3
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General Information
Symbol
Dmel\Glidv3
Species
D. melanogaster
Name
FlyBase ID
FBal0176125
Feature type
allele
Associated gene
Dmel\Gli
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Venema et al., 2004)
Progenitor genotype
GliAE2
(Venema et al., 2004)
Cytology
Description

Amino acid replacement: Q203term.

(Venema et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:15,759,539..15,759,539 [-]
Nucleotide change:

C15759539T

Amino acid change:

Q203term | Gli-PA; Q203term | Gli-PC; Q203term | Gli-PD; Q203term | Gli-PE; Q203term | Gli-PF

Reported amino acid change:

Q203term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change

(Venema et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Glidv3 significantly reduces centrosome recoil upon microtubule ablation (mean centrosome velocity relative to microtubule ablation site) compared to wild type.

      (Bosveld et al., 2016)

      Glidv5/Glidv3 animals also exhibit a wing hair chevron phenotype and patches of non-parallel alignment. This phenotype develops after prehair extension, as prehair pedestals at 38 h after puparium formation (APF) are normal in mutant wings. At 47 h APF prehair pedestals are tilted within the epithelial plane and are narrower than normal in cross section. Glidv5/Glidv3 wing cuticle remains flat in regions of disrupted hair alignment, although it appears rougher than wild-type. Blisters are also sometimes seen at the distal margin. Homozygous clones, made in the wing do not survive to adulthood.

      (Venema et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      GliAE2Δ45

      (Venema et al., 2004)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GliDV3
      (Schulte et al., 2003)
      Glidv3
      (Esmangart de Bournonville et al., 2024, Bosveld et al., 2016, Byri et al., 2015, Schulte et al., 2006)
      gliDV3
      (Mira-Osuna et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)