FlyBase Allele Report: Dmel\Gli[dv5]

General Information

Symbol

Dmel\Gli^dv5

Species

D. melanogaster

Name

FlyBase ID

FBal0176123

Feature type

allele

Associated gene

Dmel\Gli

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Venema et al., 2004)

Progenitor genotype

Gli^AE2

(Venema et al., 2004)

Cytology

Description

Amino acid replacement: G525E.

(Venema et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:15,758,516..15,758,516 [-]

Nucleotide change:

G15758516A

Amino acid change:

Reported amino acid change:

G525E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change

(Venema et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Venema et al., 2004)

abnormal cell polarity (with Gli^dv1)

(Venema et al., 2004)

abnormal cell polarity (with Gli^dv3)

(Venema et al., 2004)

abnormal cell polarity (with Gli^RAR77)

(Venema et al., 2004)

lethal (with Gli³)

(Venema et al., 2004)

lethal (with Gli^dv1)

(Venema et al., 2004)

lethal (with Gli^dv3)

(Venema et al., 2004)

partially lethal | recessive

(Venema et al., 2004)

Phenotype Manifest In

wing | distal (with Gli^dv3)

(Venema et al., 2004)

wing hair

(Venema et al., 2004)

wing hair (with Gli^dv1)

(Venema et al., 2004)

wing hair (with Gli^dv3)

(Venema et al., 2004)

wing hair (with Gli^RAR77)

(Venema et al., 2004)

Detailed Description

Statement

Reference

Unlike wild-type wings Gli^RAR77/Gli^dv5 mutant wings have regions where wing hairs are arranged in 'chevrons' on an otherwise normal wing. Homozygous mutant wings have patches of wing hairs that show disrupted alignment. Gli^dv5/Gli^RAR77, Gli^dv5/Gli^dv3 and Gli^dv5/Gli^dv1 and homozygous mutant wings also occasionally exhibit a deformed wing hair phenotype: numerous hairs are bent and abnormally thin Gli^dv5/Gli^dv3 animals also exhibit a wing hair chevron phenotype and patches of non-parallel alignment. This phenotype develops after prehair extension, as prehair pedestals at 38 h after puparium formation (APF) are normal in mutant wings. At 47 h APF prehair pedestals are tilted within the epithelial plane and are narrower than normal in cross section. Gli^dv5/Gli^dv3 wing cuticle remains flat in regions of disrupted hair alignment, although it appears rougher than wild-type. Blisters are also sometimes seen at the distal margin.

(Venema et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Gli^dv5 has phenotype, non-enhanceable by dsh¹

(Venema et al., 2004)

NOT suppressed by

Statement

Reference

Gli^dv5 has phenotype, non-suppressible by dsh¹

(Venema et al., 2004)

NOT Enhancer of

Statement

Reference

Gli^dv5 is a non-enhancer of phenotype of dsh¹

(Venema et al., 2004)

Gli^dv5 is a non-enhancer of phenotype of pk¹

(Venema et al., 2004)

NOT Suppressor of

Statement

Reference

Gli^dv5 is a non-suppressor of phenotype of dsh¹

(Venema et al., 2004)

Gli^dv5 is a non-suppressor of phenotype of pk¹

(Venema et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Gli^dv5/Gli^dv5, dsh¹/+ animals exhibit an additive wing hair phenotype. Gli^dv5/Gli^dv5, pk¹/pk¹ animals exhibit an additive wing hair phenotype.

(Venema et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Gli^AE2Δ45

(Venema et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Gli^dv5

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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