FlyBase Allele Report: Dmel\Egfr[Elp.UAS]

General Information

Symbol

Dmel\Egfr^Elp.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0176160

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

P{UAS-Egfr.Elp}

Key Links

Transgenic product class

gain_of_function_variant

(Sonnenfeld et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

gain_of_function_variant

(Sonnenfeld et al., 2004)

Mutagen

in vitro construct

(Sonnenfeld et al., 2004)

Progenitor genotype

Carried in construct

P{UAS-Egfr.Elp}

Cytology

Description

UAS regulatory sequences drive expression of a gain-of-function form of Egfr.

(Sonnenfeld et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Egfr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PF

(Sonnenfeld et al., 2004)

Phenotype Manifest In

embryonic/larval tracheal section, with Scer\GAL4^btl.PS

(Iordanou et al., 2014)

eye, with Scer\GAL4^GMR.PF

(Sonnenfeld et al., 2004)

ommatidium, with Scer\GAL4^GMR.PF

(Sonnenfeld et al., 2004)

Detailed Description

Statement

Reference

Scer\GAL4^btl.PS-mediated expression of Egfr^Elp.Scer\UAS causes extra tracheal branching.

(Iordanou et al., 2014)

Expression of Egfr^Elp.Scer\UAS under the control of Scer\GAL4^GMR.PF results in a rough eye phenotype. Expression of Egfr^Elp.Scer\UAS under the control of Scer\GAL4^sim.P3.7 in embryos does not result in a reduction in the number of midline glia.

(Sonnenfeld et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Egfr^Elp.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by jing^UAS.cSa, Scer\GAL4^GMR.PF

(Sonnenfeld et al., 2004)

Suppressor of

Statement

Reference

Scer\GAL4^sim.P3.7/Egfr^Elp.UAS is a suppressor | partially of abnormal neuroanatomy phenotype of jing³/Df(2R)ST1

(Sonnenfeld et al., 2004)

Scer\GAL4^sim.P3.7/Egfr^Elp.UAS is a suppressor of abnormal neuroanatomy phenotype of jing³

(Sonnenfeld et al., 2004)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Egfr^Elp.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by jing^UAS.cSa, Scer\GAL4^GMR.PF

(Sonnenfeld et al., 2004)

Egfr^Elp.UAS, Scer\GAL4^GMR.PF has ommatidium phenotype, non-enhanceable by jing^UAS.cSa, Scer\GAL4^GMR.PF

(Sonnenfeld et al., 2004)

NOT suppressed by

Statement

Reference

Egfr^Elp.UAS, Scer\GAL4^btl.PS has embryonic/larval tracheal section phenotype, non-suppressible by exp¹³⁵

(Iordanou et al., 2014)

Enhancer of

Statement

Reference

Scer\GAL4^btl.PS/Egfr^Elp.UAS is an enhancer of embryonic/larval tracheal lateral trunk phenotype of exp¹³⁵

(Iordanou et al., 2014)

Scer\GAL4^btl.PS/Egfr^Elp.UAS is an enhancer of embryonic/larval ganglionic tracheal branch phenotype of exp¹³⁵

(Iordanou et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^sim.P3.7/Egfr^Elp.UAS is a suppressor | partially of larval ventral midline glial cell phenotype of jing³/Df(2R)ST1

(Sonnenfeld et al., 2004)

Scer\GAL4^sim.P3.7/Egfr^Elp.UAS is a suppressor of larval ventral midline glial cell phenotype of jing³

(Sonnenfeld et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^btl.PS-mediated expression of Egfr^Elp.Scer\UAS enhances the tracheal cyst phenotype of exp¹³⁵ embryos.

(Iordanou et al., 2014)

The rough eye phenotype caused by expression of Egfr^Elp.Scer\UAS under the control of Scer\GAL4^GMR.PF is not enhanced by coexpression of jing^Scer\UAS.cSa. Expression of Egfr^Elp.Scer\UAS under the control of Scer\GAL4^sim.P3.7 reduces the penetrance of the loss of midline glia phenotype seen in homozygous jing³ embryos, so that only 20% of double mutant embryos have a reduced number of midline glial cells. Expression of Egfr^Elp.Scer\UAS under the control of Scer\GAL4^sim.P3.7 reduces the penetrance of the loss of midline glia phenotype seen in jing³/Df(2R)ST1 embryos.

(Sonnenfeld et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

J.R. Jacobs

(Sonnenfeld et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Egfr^Elp.Scer\UAS

Egfr^Elp.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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