FlyBase Allele Report: Dmel\Cap-G[K1]

General Information

Symbol

Dmel\Cap-G^K1

Species

D. melanogaster

Name

FlyBase ID

FBal0176323

Feature type

allele

Associated gene

Dmel\Cap-G

Associated Insertion(s)

Carried in Construct

Also Known As

dcap-g^K1

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Dej et al., 2004)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with Cap-G^Z1)

(Resnick et al., 2009)

female sterile (with Cap-G^Z2)

(Resnick et al., 2009)

lethal (with Cap-G^EP2346)

(Dej et al., 2004)

lethal | recessive

(Dej et al., 2004)

suppressor of variegation | dominant, with In(1)w^m4h

(Dej et al., 2004)

Phenotype Manifest In

anaphase & condensed nuclear chromosome

(Dej et al., 2004)

anaphase & condensed nuclear chromosome (with Df(2R)vg56)

(Dej et al., 2004)

Detailed Description

Statement

Reference

Defects in sister chromatid separation are seen at anaphase during cycle 15 of embryogenesis in mutant embryos; bridging of one or two chromosome arms is seen. At anaphase, Cap-G^K1/Df(2R)vg56 mutant postblastoderm embryos show failure of sister chromatid separation and bridging of chromosomes is seen.

(Dej et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Chromatin condenses nonuniformly in prophase and prometaphase in postblastoderm Cap-G^K1 barr^L305 double mutant embryos. By metaphase, chromosome condensation has reached wild-type levels. Chromatid separation defects are seen in anaphase when only the fourth chromosome is clearly seen to separate, and lagging chromosomes are seen in telophase. The double mutant postblastoderm embryos have an increased number of prometaphase figures compared to wild-type embryos, suggesting that the length of prometaphase may be increased in the mutant embryos.

(Dej et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Cap-G^Z2

(Resnick et al., 2009)

Cap-G^Z1

(Resnick et al., 2009)

Cap-G^EP2346

(Dej et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cap-G^K1

dcap-g^K1

(Resnick et al., 2009, Dej et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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