FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tgoΔc.UAS
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General Information
Symbol
Dmel\tgoΔc.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0177502
Feature type
allele
Associated gene
Dmel\tgo
Associated Insertion(s)
Carried in Construct
P{UAS-tgo.Δc}
Key Links
Transgenic product class
inframe_deletion
(Sonnenfeld et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Sonnenfeld et al., 2005)
Mutagen
in vitro construct
(Sonnenfeld et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-tgo.Δc}
Cytology
Description

UAS regulatory sequences drive expression of a deleted form of tgo which lacks the C-terminal transactivation domains and Paired repeat.

(Sonnenfeld et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
tgo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of tgoΔc.Scer\UAS under the regulation of Scer\GAL4sim.P3.7 in the central nervous system midline is associated with alterations in commissural and longitudinal axon formation. Longitudinal connectives are thinner than in wild-type embryos and the commissural axons are either not properly separated or do not form at all. Expression of tgoΔc.Scer\UAS under the regulation of Scer\GAL4btl.PS results in a reduction in the number of btl-expressing embryonic midline glia compared to wild-type. In the trachea, there are reductions in the number of cells expressing btl in the dorsal trunk, ganglionic branches and dorsal branches compared with wild-type embryos.

      (Sonnenfeld et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of tgoΔc.Scer\UAS and trhScer\UAS.cWa under the control of either Scer\GAL4GMR.PF or Scer\GAL4elav-C155 does not result in a rough eye phenotype.

      (Sonnenfeld et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tgoΔc.Scer\UAS
      tgoΔc.UAS
      tgoΔc
      (Sonnenfeld et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)