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General Information
Symbol
Dmel\RtGEFp1036
Species
D. melanogaster
Name
FlyBase ID
FBal0178146
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dPixP1036
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{EP} insertion into 5' part of rtGEF intron 1.

Insertion components
P{EP}RtGEFp1036
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones generated using the eyFLP system do not result in any obvious overgrowth of the adult head.

rtGEFp1036/Df(2L)PJ19 mutants lack the subsynaptic reticulum at the synapse of muscles 6 and 7 in third instar larvae. Additionally, these mutants have a greater number of T bars at the presynaptic active zone and there is an excess of vesicles in the terminal, which are larger than those of wild type, although vesicles in the mutant are able to dock at T bars. Further, boutons appear flatter than in wild type. Evoked excitatory junctional potentials (EJPs) are reduced and there is a greater variation in EJP amplitude per muscle in rtGEFp1036/Df(2L)PJ19 mutants compared to wild type. While the amplitude of miniature EJPs is somewhat reduced in mutants, there is a large reduction in their frequency, indicating a presynaptic defect. Quantal content is slightly higher in rtGEFp1036/Df(2L)PJ19 mutants than in wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Double homozygous ft8, RtGEFp1036 clones generated using the eyFLP system result in substantial overgrowth of the head, particularly in the ptilinum.

The increase in the number of interommatidial cells which is seen in homozygous hpoMGH1 clones generated using the eyFLP system is enhanced if the clones are also homozygous for RtGEFp1036.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Symbol Synonym
RtGEFp1036
rtGEFp1036
Name Synonyms
Secondary FlyBase IDs
    References (6)