FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.
Robust induction of apoptosis after ionizing irradiation is observed in wild-type embryos, but not in p53unspecified animals.
The initial movements of the primordial germ cells (PGCs) appear normal in stage 10 mutant embryos. The PGCs form bilateral clusters in mutant embryos at stages 11 and 12, as occurs in wild type, but some PGCs are occasionally left at the midline in the mutant embryos (this also occurs in wild-type embryos). Between stages 11 and 13, any PGCs at the midline in wild-type embryos appear to undergo programmed cell death, but this does not occur in the mutant embryos, so that at stage 13, some isolated PGCs are seen in the mutant embryos even though most are aligned in linear arrays, as occurs in wild type. PGCs are able to migrate to the gonads in stage 14 mutant embryos, but many PGCs also exist ectopic to the gonads.
The reduction in electroretinogram (ERG) amplitude seen in flies exposed to constant light is not significantly affected by p53unspecified.
okrAA/okrRU, p53unspecified has female sterile phenotype, suppressible by mei-W681
p53unspecified is a suppressor of increased cell death phenotype of nbs1
p53unspecified is a non-suppressor of abnormal developmental rate | first instar larval stage phenotype of Tif-IAKG06857
p53unspecified is a non-suppressor of lethal | first instar larval stage phenotype of Tif-IAKG06857
okrAA/okrRU, p53unspecified has female sterile phenotype
okrAA/okrRU, p53unspecified has nurse cell phenotype, suppressible by mei-W681
okrAA/okrRU, p53unspecified has nurse cell phenotype
Single-gene mutants show 15 nurse cell nuclei per egg chamber, but p53unspecified, okrAA/okrRU ovaries exhibit a broad distribution, ranging from 9 to 40 nuclei per egg chamber, which is restored to normal in mei-W681, okrAA/okrRU, p53unspecified animals.
Single-gene mutants are fertile, but p53unspecified, okrAA/okrRU double mutants are sterile. Fertility is restored in mei-W681, okrAA/okrRU, p53unspecified triple mutant females.
A p53unspecified mutant background does not suppress the growth arrest phenotypes observed in Tif-IAKG06857 homozygous mutants.
tefustg p53unspecified double mutants show the same checkpoint phenotype as tefustg single mutants; they show a normal checkpoint response to irradiation with 4000 rad of X rays, but they are unable to block mitotic entry when irradiated with 500 rad. tefuwk p53unspecified double mutants show the same checkpoint phenotype as tefuwk single mutants; they show a normal checkpoint response to irradiation with 4000 rad of X rays, but they are unable to block mitotic entry when irradiated with 500 rad. mre11Δ35K1 p53unspecified double mutants show the same checkpoint phenotype as mre11Δ35K1 single mutants; they show a normal checkpoint response to irradiation with 4000 rad of X rays, but they are unable to block mitotic entry when irradiated with 500 rad.
