FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\brunZ0704
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General Information
Symbol
Dmel\brunZ0704
Species
D. melanogaster
Name
FlyBase ID
FBal0180655
Feature type
allele
Associated gene
Dmel\brun
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Giansanti et al., 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?755term.

(Robinett et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:20,653,292..20,653,292 [-]
Nucleotide change:

C20653292T

Amino acid change:

Q755term | brun-PA

Reported amino acid change:

?755term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Reported as a truncation of the polypeptide after residue 754.

(Robinett et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      bruZ0704/Df(2L)pr2b spermatocytes fail to undergo meiotic cytokinesis at 25[o]C. This phenotype is exacerbated at 29[o]C and suppressed at 18[o]C.

      (Robinett et al., 2009)

      A large proportion of bruZ0704 mutant spermatids have one large nebenkern with two nuclei of normal size, indicating failure of cytokinesis in one of the meiotic divisions. Further, many spermatids have four nuclei and a large nebenkern, indicating a cytokinetic failure in both meiotic divisions. A small proportion (<2%) of bruZ0704 spermatids have three nuclei, which may be due to failure of cytokinesis in the first meiotic division, followed by budding off of only one daughter cell in the second meiotic division. Additionally, some spermatids (<3% of cases) have more than four nuclei, which may result from defects in the mitotic divisions preceding mitosis.

      (Giansanti et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Testes from bruZ0704/bruZ3358, fwdZ0453/Df(3L)7C males produce higher percentages of multi-nucleate early spermatids associated with enlarged mitochondrial derivatives than testes from siblings containing one mutant and one wild type copy of either bru or fwd.

      The elongation of later-stage spermatids is defective in bruZ0704/bruZ3358, fwdZ0453/Df(3L)7C testes.

      The percentage of tetranucleate early spermatids in testes from bruZ0704/bruZ3358, pbl5/pblZ4836 males is similar to that of testes from pbl5/pblZ4836 males that are heterozygous for a bru mutation, indicating a lack of genetic interaction between bru and pbl.

      Mitotic cytokinesis appears normal in bruZ0704/bruZ3358, fwdZ0453/Df(3L)7C third instar larval brains.

      (Robinett et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      bruZ0704
      (Robinett et al., 2009)
      brunZ0704
      Name Synonyms
      Secondary FlyBase IDs
        References (2)